Month: June 2024

Novo Nordisk braces for generic challenge to Ozempic, Wegovy in China

SHANGHAI, China — Novo Nordisk is facing the prospect of intensifying competition in the promising Chinese market, where drugmakers are developing at least 15 generic versions of its diabetes drug Ozempic and weight loss treatment Wegovy, clinical trial records showed.

The Danish drugmaker has high hopes that demand for its blockbuster drugs will surge in China, which is estimated to have the world’s highest number of people who are overweight or obese.

Ozempic won approval from China in 2021, and Novo Nordisk saw sales of the drug in the greater China region double to $698 million last year. It is expecting Wegovy to be approved this year.

But the patent on semaglutide, the active ingredient in both Wegovy and Ozempic, expires in China in 2026. Novo is also in the midst of a legal fight in the country over the patent.

An adverse court ruling could make it lose its semaglutide exclusivity even sooner and turn China into the first major market where Novo is stripped of patent protection for the drugs.

Those circumstances have drawn several Chinese drugmakers to the fray. At least 11 semaglutide drug candidates from Chinese firms are in the final stages of clinical trials, according to records in a clinical trial database reviewed by Reuters.

“Ozempic has witnessed unprecedented success in mainland China … and with patent expiry so close, Chinese drugmakers are looking to capitalize (on) this segment as soon as possible,” said Karan Verma, a health care research and data analyst at information services provider Clarivate.

Front-runner Hangzhou Jiuyuan Gene Engineering has already developed one treatment that it says has “similar clinical efficacy and safety” as Ozempic and applied for approval for sale in April. The company has not published efficacy data and did not respond to a request for information.

The company said in January that it expected approval in the second half of 2025, but it cautioned that it would not be able to commercialize the drug before Novo’s patent expires in 2026, unless a Chinese court makes a final ruling that the patent is invalid.

The Danish company’s semaglutide patent is expiring in China far ahead of its expiry in key markets such as Japan, Europe and the U.S. Analysts attribute variations in patent expiry timelines to term extensions Novo has won in specific regions.

Even more pressing for Novo is the China patent office’s 2022 ruling that the patent is invalid for reasons related to experimental data availability, which the company has challenged.

China’s top court said it was not able to say when verdicts are likely ready.

A Novo spokesperson said it “welcomes healthy competition” and was awaiting a court decision on its patent case. The spokesperson did not answer follow-up queries on the matter.

Other Chinese drugmakers who are running the final stages of clinical trials for Ozempic generics include United Laboratories, CSPC Pharmaceutical Group, Huadong Medicine and a subsidiary of Sihuan Pharmaceutical Holdings Group.

CSPC said in May it expected approval for its semaglutide diabetes drug in 2026.

Brokerage Jefferies estimated in an October report that semaglutide drugs from United Laboratories will be launched for diabetes in 2025 and obesity in 2027. United Laboratories did not respond to a request for comment.

Impact on prices

The number of adults who are overweight or obese in China is projected to reach 540 million and 150 million, respectively, in 2030, up 2.8 and 7.5 times from 2000 levels, according to a 2020 study by Chinese public health researchers.

If shown to be as safe and effective as Novo’s, Chinese drugmakers’ products will increase competition and bring down prices, analysts say.

Goldman Sachs analysts estimated in an August report that generics could lead to a price reduction of around 25% for semaglutide in China. The weekly Ozempic injection costs around $100 for each 3mL dose through China’s public hospital network, Clarivate’s Verma said.

Novo acknowledges the intensifying competition.

“In 2026 and 2027 we might see a few more players showing up due to the clinical trials” in progress, Maziar Mike Doustdar, a Novo executive vice president, told investors in March, referring to the China market.

But he also questioned the capability of some of the players to provide meaningful volumes, adding, “We will watch it as we get closer.”

Novo also faces competition from internationally well-known firms, including Eli Lilly, whose diabetes drug Mounjaro received approval from China in May. HSBC analysts expect China’s approval this year or in the first half of 2025 for Lilly’s weight loss drug with the same active ingredient.

Eli Lilly did not reply to a request for a comment on Chinese approval of the drug, which in the U.S. is called Zepbound.

Supplies of both Wegovy and Zepbound remain constrained, but the companies have been increasing production.

Zuo Ya-Jun, general manager of weight loss drugmaker Shanghai Benemae Pharmaceutical, said a product being competitive would depend on distinguishing features such as efficacy, durability of the treatment and a company’s sales abilities.

“It will be a market with fierce competition, but who will be [the leader] is hard to say,” she said.

From refugee camps to World Cup glory: Inspiring journey of Afghanistan cricket

Washington — When the parents of Karim Sadiq and Taj Maluk fled a wrecked Afghanistan torn apart by the 1979 Soviet invasion and infighting warlords, they didn’t imagine their children — Karim and Taj — would return to reunite the war-torn nation through cricket. 

Taj Maluk became the first coach of the Afghan national team. Fans refer to him as one of the founding fathers of Afghan cricket. Younger brother Karim Sadiq played a key role in Afghanistan’s qualification in the World Cup in 2010, creating history for the cricket-loving nation of more than 40 million. 

The brothers were brought up in a refugee camp called Katcha Garhi, in Peshawar, Pakistan. The family left a decent life in the eastern Nangarhar province to live in a sea of mud houses and poverty. 

“Life was all struggle those days,” Karim Sadiq recalls. “Doing odd jobs in the night and playing cricket in the daytime. We used a stick as a bat, used to make plastic balls from plastic waste material.” 

There was an old black-and-white TV set in their refugee camp where the young and elders watched international matches, including Pakistan winning the 1992 World Cup. These events had a huge influence on aspiring cricketers in Afghan refugee camps. 

The elder brother, Taj Maluk, searched for talent in refugee camps and founded the Afghan Cricket Club, which arguably laid the foundation of the future Afghanistan team. 

Another Afghan cricketer, Allah Dad Noori, also played a key role by pioneering a path for cricket in Afghanistan. 

Like the brothers, many international Afghan players, such as Mohammad Shehzad, Raees Ahmadzai, Mohammad Nabi, and the country’s first global star Rashid Khan, now captain, all grew up learning cricket and becoming cricketers in Peshawar, Pakistan. 

“It was our passion. We didn’t know then that Cricket would bring such happiness to the Afghan nation,” Karim Sadiq told VOA. “Cricket conveys a message that Afghanistan is not a country of war and drugs. It’s a country of love and sports.” 

In 2001, after the invasion of the U.S. forces against the Taliban rule, cricket flourished in Afghanistan, which became an associate member of the ICC, the world’s cricketing body. 

A new younger generation of cricketers emerged. Now, Afghanistan is a full member of the ICC’s elite club of 12 countries, and it enjoys the status of a test-playing nation. 

The Afghan team won many hearts in the 2023 World Cup after earning wins against the former world champions — Pakistan, England and Sri Lanka. 

“Afghan players fight for every match as they are fighting for the nation,” Pakistan’s former captain, Rashid Latif, who coached Afghanistan, told VOA. “T20 cricket needs aggression and Afghanistan players have it. They are capable of surprises in the World Cup.” 

Now, Afghanistan is playing in the T20 Cricket World Cup co-hosted by the United States and West Indies. It has strong contenders like New Zealand and West Indies in the group, along with minnows Papa New Guinea and Uganda. Some experts call it the “Group of Death” because only two teams will make it through the knockout stage. 

The Taliban banned all women’s sports and put restrictions on some men’s sports, but not cricket. There is speculation it’s because they enjoyed the game themselves or were apprehensive about the possible public reaction if they banned it, given its massive popularity. 

A few weeks ago, when Afghanistan’s team captain, Rashid Khan, visited Afghanistan to meet family and friends, Taliban officials presented him with bouquets and took selfies with the superstar. 

Rashid and his team members, including young superstars — batters Rehmanullah Gurbaz and Ibrahim Zadran, allrounder Azmatullah Omarzai, spinners Mujeeb-ur Rehman and Noor Ahmed — have arrived in the West Indies, as have their diehard supporters from Europe, Canada and the U.S. 

Back in Afghanistan, Karim Sadiq is now working to promote the sport, while his elder brother, 49-year-old Taj Maluk, has turned to religion. “Cricket is not just a game. It reunites Afghans and brings joy to the lives of people,” Taj Maluk told VOA. “We will pray for their success.” 

Karim Sadiq recalls when Afghanistan qualified for the T20 World Cup in 2010. “When we returned home, it was a festival. Everywhere, celebrating crowds held up the Afghan flag. We all wish to see such festivity again, to see Afghanistan become the World Champion.” 

Across Afghanistan, fans have made special arrangements to view the matches. Some have pooled their money to buy dish antennas. Others have decorated the hujras, or living rooms, with national flags. 

“Afghanistan is a wounded land. Cricket helps people stitch those wounds,“ said Shams ul Rahman Shirzad, a cricket fan in Nangarhar, from where the brothers Taj Maluk and Karim Sadiq hailed and once dreamed of having a national cricket team.  

This story originated in VOA’s Afghan service.

UN chief warns target to limit global warming is slipping away

NEW YORK — The U.N. secretary-general said Wednesday that the world is “at a moment of truth” to reach targets in the 2015 Paris climate accord to limit global warming, as the planet has just experienced the 12 hottest consecutive months on record.

“The truth is, almost ten years since the Paris Agreement was adopted, the target of limiting long-term global warming to 1.5 degrees Celsius is hanging by a thread,” Antonio Guterres told an audience at New York’s American Museum of Natural History, where exhibits about extinct dinosaurs offered their own planetary warning.

“The World Meteorological Organization reports today that there is an 80% chance the global annual average temperature will exceed the 1.5-degree limit in at least one of the next five years,” he said.

“We are playing Russian roulette with our planet,” he warned in a special climate speech under the museum’s famous blue whale, marking World Environment Day.

The U.N. chief said the richest 1% of countries are emitting as much pollution as two-thirds of all humanity.

He said the planet is emitting around 40 billion tons of carbon dioxide annually and will burn through its remaining “carbon budget” of around 200 billion tons well before 2030. Guterres also said global emissions need to fall 9% each year between now and 2030 in order to keep the 1.5 degree Celsius limit alive. Last year, they rose by 1%.

The bill for the climate crisis will keep growing without meaningful action.

“Even if emissions hit zero tomorrow, a recent study found that climate chaos will still cost at least $38 trillion a year by 2050,” Guterres said.

Fossil fuels

The climate crisis has been a signature issue of Guterres’ tenure since becoming the world’s top diplomat seven-and-a-half years ago. He has repeatedly called for the phasing out of coal and other fossil fuels in favor of cleaner renewable energies like wind and solar power — which already produce nearly a third of the world’s electricity.

He raised the ante Wednesday, urging banks to stop financing oil, coal and gas and invest in renewables instead. He called on countries to ban advertising from fossil fuel producers and said news and technology platforms should stop taking their advertising.

“I call on leaders in the fossil fuel industry to understand that if you are not in the fast lane to clean energy transformation, you are driving your business into a dead end — and taking us all with you,” the U.N. chief said, adding that the oil and gas industry invested only 2.5% of its total spending on clean energy in the last year.

He urged public relations companies and lobbyists to stop enabling the industry’s “planetary destruction” and drop those clients.

“Many in the fossil fuel industry have shamelessly greenwashed, even as they have sought to delay climate action — with lobbying, legal threats, and massive ad campaigns,” he said.

Leveling the field

The secretary-general reiterated his stance that those who have contributed the least to the climate crisis are suffering the most — mainly poorer nations in Africa and small island states. The G20 major economies produce 80% of the world’s emissions.

“It is a disgrace that the most vulnerable are being left stranded, struggling desperately to deal with a climate crisis they did nothing to create,” he said.

Guterres warned that the difference between 1.5 and 2 degrees could mean survival or extinction for some small island nations and coastal communities.

“1.5 degrees is not a target. It is not a goal. It is a physical limit,” he said.

Global warming is already hurting the planet’s oceans, their coral reefs and marine ecosystems, and melting sea ice. Across the globe, severe floods, droughts, heatwaves, wildfires, and other climate-related catastrophes are becoming all too frequent.

The secretary-general said there must be more financing and technical support from richer countries to mitigate climate impacts and invest in renewables for lower income states. He also said a global early warning system must be in place by 2027, to protect everyone on Earth from hazardous weather, water or climate events.

He urged citizens to continue to make their voices heard and said it is time for leaders to decide whose side they are on.

“Now is the time to mobilize; now is the time to act; now is the time to deliver,” he said to a standing ovation. “This is our moment of truth.”

Panel rejects psychedelic drug MDMA as a PTSD treatment

washington — Federal health advisers voted Tuesday against a first-of-a-kind proposal to begin using the mind-altering drug MDMA as a treatment for PTSD, handing a potentially major setback to advocates who had hoped to win a landmark federal approval and bring the banned drugs into the medical mainstream. 

The panel of advisers to the Food and Drug Administration sided 10-1 against the overall benefits of MDMA when used to treat post-traumatic stress disorder. They cited flawed study data, questionable research conduct and significant drug risks, including the potential for heart problems, injury and abuse. 

“It seems like there are so many problems with the data — each one alone might be OK, but when you pile them on top of each other … there’s just a lot of questions I would have about how effective the treatment is,” said Dr. Melissa Decker Barone, a psychologist with the Department of Veterans Affairs. 

The FDA is not required to follow the group’s advice and is expected to make its final decision by August, but the negative opinion could strengthen FDA’s rationale for rejecting the treatment. 

The vote followed hours of pointed questions and criticisms about the research submitted on MDMA — sometimes called ecstasy or molly. Panelists pointed to flawed studies that could have skewed the results, missing follow-up data on patient outcomes, and a lack of diversity among participants. The vast majority of patients studied were white, with only five Black patients receiving MDMA, raising questions about the generalizability of the results. 

“The fact that this study has so many white participants is problematic because I don’t want something to roll out that only helps this one group,” said Elizabeth Joniak-Grant, the group’s patient representative. 

The FDA advisers also drew attention to allegations of misconduct in the trials that have recently surfaced in news stories and a report by the nonprofit Institute for Clinical and Economic Review, which evaluates experimental drug treatments. The incidents include a 2018 report of apparent sexual misconduct by a therapist interacting with a patient. 

Lykos Therapeutics, the company behind the study, said it previously reported the incident to the FDA and regulators in Canada, where the therapist is based. Lykos is essentially a corporate spinoff of the nation’s leading psychedelic advocacy group, the Multidisciplinary Association for Psychedelic Studies, or MAPS, which funded the studies. The group was founded in 1986 to promote the benefits of MDMA and other mind-altering substances. 

MDMA is the first in a series of psychedelics — including LSD and psilocybin — that are expected to come before the FDA in the next few years. The panel’s negative ruling could further derail financial investments in the fledgling industry, which has mainly been funded by a small number of wealthy backers. 

MDMA’s main effect is triggering feelings of intimacy, connection and euphoria. When used to enhance talk therapy, the drug appears to help patients process their trauma and let go of disturbing thoughts and memories. 

But the panel struggled with the reliability of those results, given the difficulties of objectively testing psychedelic drugs. 

Because MDMA causes intense, psychological experiences, almost all patients in two key studies of the drug were able to guess whether they had received the MDMA or a dummy pill. That’s the opposite of the approach generally required for high-quality drug research, in which bias is minimized by “blinding” patients and researchers to whether they received the drug under investigation. 

“I’m not convinced at all that this drug is effective based on the data I saw,” said Dr. Rajesh Narendran, a University of Pittsburgh psychiatrist who chaired the panel. 

Panelists also noted the difficulty of knowing how much of patients’ improvement came from MDMA versus simply undergoing the extensive therapy, which totaled more than 80 hours for many patients. Results were further marred by other complicating factors, including a large number of patients who had previously used MDMA or other psychedelics drugs recreationally. 

Saudi Arabia warns of above-average heat during Hajj

Riyadh, Saudi Arabia — Saudi Arabia said Tuesday pilgrims can expect average high temperatures of 44 degrees Celsius (111 Fahrenheit) during the Hajj, which last year saw thousands of cases of heat stress.

“The expected climate for Hajj this year will witness an increase in average temperatures of 1½  to 2 degrees above normal in Mecca and Medina,” national meteorology center chief Ayman Ghulam told a press conference.

The forecast indicates “relative humidity 25%, rain rates close to zero, average maximum temperature 44 degrees,” he said.

The Hajj, which begins on June 14, is one of the five pillars of Islam and must be undertaken at least once by all Muslims who have the means to do so.

It involves a series of rites completed over four days in Mecca and its surroundings in the west of oil-rich Saudi Arabia.

Last year more than 1.8 million Muslims took part in the Hajj, official figures showed.

More than 2,000 people suffered heat stress, according to Saudi authorities, after temperatures soared to 48 degrees Celsius (118 degrees Fahrenheit).

The real number of heat stress cases — which includes heatstroke, exhaustion, cramps and rashes — was probably far higher, as many sufferers were not admitted to hospitals or clinics.

At least 240 people — many from Indonesia — died during the pilgrimage, according to figures announced by various countries that did not specify causes of death.

Saudi Arabia did not provide statistics on fatalities.

Officials in the kingdom take steps to try to mitigate the effects of heat, including providing air-conditioned tents and misting systems.

Ghulam told Tuesday’s press conference there was “a need for sufficient quantities of water to cover daily consumption as temperatures rise.”

He also said food for pilgrims should be transported in refrigerators so it does not spoil.

Many Americans still shying away from EVs despite Biden’s push, poll finds

Washington — Many Americans still aren’t sold on going electric for their next car purchase. High prices and a lack of easy-to-find charging stations are major sticking points, a new poll shows.  

About 4 in 10 U.S. adults say they would be at least somewhat likely to buy an EV the next time they buy a car, according to the poll by The Associated Press-NORC Center for Public Affairs Research and the Energy Policy Institute at the University of Chicago, while 46% say they are not too likely or not at all likely to purchase one.  

The poll results, which echo an AP-NORC poll from last year, show that President Joe Biden’s election-year plan to dramatically raise EV sales is running into resistance from American drivers. Only 13% of U.S. adults say they or someone in their household owns or leases a gas-hybrid car, and just 9% own or lease an electric vehicle.  

Caleb Jud of Cincinnati said he’s considering an EV, but may end up with a plug-in hybrid — if he goes electric. While Cincinnati winters aren’t extremely cold, “the thought of getting stuck in the driveway with an EV that won’t run is worrisome, and I know it wouldn’t be an issue with a plug-in hybrid,″ he said. Freezing temperatures can slow chemical reactions in EV batteries, depleting power and reducing driving range.

A new rule from the Environmental Protection Agency requires that about 56% of all new vehicle sales be electric by 2032, along with at least 13% plug-in hybrids or other partially electric cars. Auto companies are investing billions in factories and battery technology in an effort to speed up the switch to EVs to cut pollution, fight climate change — and meet the deadline.  

EVs are a key part of Biden’s climate agenda. Republicans led by presumptive nominee Donald Trump are turning it into a campaign issue.  

Younger people are more open to eventually purchasing an EV than older adults. More than half of those under 45 say they are at least “somewhat” likely to consider an EV purchase. About 32% of those over 45 are somewhat likely to buy an EV, the poll shows.  

But only 21% of U.S. adults say they are “very” or “extremely” likely to buy an EV for their next car, according to the poll, and 21% call it somewhat likely. Worries about cost are widespread, as are other practical concerns.  

Range anxiety – the idea that EVs cannot go far enough on a single charge and may leave a driver stranded — continues to be a major reason why many Americans do not purchase electric vehicles.  

About half of U.S. adults cite worries about range as a major reason not to buy an EV. About 4 in 10 say a major strike against EVs is that they take too long to charge or they don’t know of any public charging stations nearby.  

Concern about range is leading some to consider gas-engine hybrids, which allow driving even when the battery runs out. Jud, a 33-year-old operations specialist and political independent, said a hybrid “is more than enough for my about-town shopping, dropping my son off at school” and other uses.  

With EV prices declining, cost would not be a factor, Jud said — a minority view among those polled. Nearly 6 in 10 adults cite cost as a major reason why they would not purchase an EV.  

Price is a bigger concern among older adults.  

The average price for a new EV was $52,314 in February, according to Kelley Blue Book. That’s down by 12.8% from a year earlier, but still higher than the average price for all new vehicles of $47,244, the report said.

Jose Valdez of San Antonio owns three EVs, including a new Mustang Mach-E. With a tax credit and other incentives, the sleek new car cost about $49,000, Valdez said. He thinks it’s well worth the money.  

“People think they cost an arm and a leg, but once they experience (driving) an EV, they’ll have a different mindset,” said Valdez, a retired state maintenance worker. 

The 45-year-old Republican said he does not believe in climate change. “I care more about saving green” dollars, he said, adding that he loves the EV’s quiet ride and the fact he doesn’t have to pay for gas or maintenance. EVs have fewer parts than gas-powered cars and generally cost less to maintain. Valdez installed his home charger himself for less than $700 and uses it for all three family cars, the Mustang and two older Ford hybrids.

With a recently purchased converter, he can also charge at a nearby Tesla supercharger station, Valdez said.  

About half of those who say they live in rural areas cite lack of charging infrastructure as a major factor in not buying an EV, compared with 4 in 10 of those living in urban communities.  

Daphne Boyd, of Ocala, Florida, has no interest in owning an EV. There are few public chargers near her rural home “and EVs don’t make any environmental sense,″ she said, citing precious metals that must be mined to make batteries, including in some countries that rely on child labor or other unsafe conditions. She also worries that heavy EV batteries increase wear-and-tear on tires and make the cars less efficient. Experts say extra battery weight can wear on tires but say proper maintenance and careful driving can extend tire life.  

Boyd, a 54-year-old Republican and self-described farm wife, said EVs may eventually make economic and environmental sense, but “they’re not where they need to be” to convince her to buy one now or in the immediate future.

Ruth Mitchell, a novelist from Eureka Springs, Arkansas, loves her EV. “It’s wonderful — quiet, great pickup, cheap to drive. I rave about it on Facebook,″ she said.

Mitchell, a 70-year-old Democrat, charges her Chevy Volt hybrid at home but says there are several public chargers near her house. She’s not looking for a new car, Mitchell said, but when she does it will be electric: “I won’t drive anything else.”

Mick Jagger, strutting at 80, teases new album and more touring

Los Angeles — How does it feel for Mick Jagger to be back on tour singing, dancing and strutting across stadium concert stages at 80 years old?

“Like being on stage at 78,” the Rolling Stones frontman, who has thrilled audiences for more than six decades, said a day after playing a packed show outside Boston.

“It took a couple of shows to get into the groove, but now we’re into it,” Jagger said. “I’m feeling good.”

He sang “What a drag it is getting old,” back in the 1960s. But Jagger, who turns 81 on July 26, is still having a blast and has no plans to stop rocking anytime soon.

Now swinging through the U.S. on the “Hackney Diamonds” tour, the group will look at opportunities to play in other countries next year, Jagger said in an interview.

“We’ll consider those offers, where we’re going to go and where it will be fun, you know?” he said. “It could be Europe, could be South America, could be anywhere.”

Jagger also said the Stones are likely to release more new music soon.  

The current tour is named for the critically praised album the Stones debuted last October, the first new material from the British rockers in 18 years.

At each stop, Jagger commands the stage for two hours with bandmates Keith Richards, 80, and Ronnie Wood, 77. Fans say Jagger still delivers a vigorous performance full of gyrating, stomping, sprinting and his world-famous swagger.

In a review titled “The Rolling Stones Really Might Never Stop,” the New York Times said Jagger, at a show at a football stadium in New Jersey, seemed to get more energetic as the night went on.

Where does he find such energy?

“I just enjoy it,” Jagger said. “Really, that’s the answer. I just love doing it.

“You get this back and forth with the audience. You can see they’re having a good time, you’re having a good time, and it gives you a lot more energy.”

Music legends may join Jagger

Jagger said he stays fit by doing two dance rehearsals and a few gym workouts each week. His father was a physical education teacher and Jagger has often credited his good health to genetics.

On the tour, the Stones play about four songs from “Hackney Diamonds” in between rock classics such as “Start Me Up,” “(I Can’t Get No) Satisfaction” and “Sympathy for the Devil.” The set list is tweaked for each stop.

Fans appear to have embraced the new music, Jagger said. He sees people in the crowd singing along to the words.

Coming up, Jagger said he hopes to be joined on stage by some of the music legends who made guest appearances on “Hackney Diamonds” – Paul McCartney, Lady Gaga, Stevie Wonder and Elton John – but said he does not yet have commitments. “It’s hard pinning them down,” he said.

The Stones recorded many songs that did not make it onto “Hackney Diamonds,” which may lead to another album, Jagger said.

“We’ve got a lot more, so I think we may be set up to make another album quite soon,” he said.

Outside of music, Jagger is producing a film about the love story between jazz musician Miles Davis and French actress and singer Juliette Greco, as well as a movie adaptation of “The Real Thing,” a play by British playwright Tom Stoppard.

Jagger has appeared on screen in about a dozen films and TV shows and said he would like to do more acting. “I don’t really get that many interesting offers, to be honest,” he said. “I enjoy doing it when I do it.”

Interest in U.S. elections

On the tour, the band asks ticket holders at each stop to vote on one song to be included in that night’s show. Boston fans chose 1980 track “Emotional Rescue” in the online poll, which had a turnout of roughly 80%.

Jagger used the moment to urge the audience to vote in the U.S. presidential election in November.

He did not say which candidate he preferred, but the band has threatened to sue likely Republican nominee Donald Trump if his campaign keeps playing the Stones hit “You Can’t Always Get What You Want” at events.

Jagger has made brief political jabs on stage and occasionally receives flack as a Brit commenting on American politics.

“First of all, I think everyone has a right to have an opinion,” Jagger said. “It’s a free country.”

“I feel like it’s such an important election,” he added.

“I’ve got seven children who are U.S. citizens. I care about what happens to their future. And I pay a lot of American taxes. So why shouldn’t I be able to say what I feel?”

Algeria seeks to lure tourists to neglected cultural, scenic glories

ORAN, Algeria — Algeria wants to lure more visitors to the cultural and scenic treasures of Africa’s largest country, shedding its status as a tourism backwater and expanding a sector outshone by competitors in neighboring Morocco and Tunisia.  

The giant north African country offers Roman and Islamic sites, beaches and mountains just an hour’s flight from Europe, and haunting Saharan landscapes, where visitors can sleep on dunes under the stars and ride camels with Tuareg nomads.  

But while tourist-friendly Morocco welcomed 14.5 million visitors in 2023, bigger, richer Algeria hosted just 3.3 million foreign tourists, according the tourism ministry.  

About 1.2 million of those holiday-makers were Algerians from the diaspora visiting families.  

The lack of travelers is testimony to Algeria’s neglect of a sector that remains one of world tourism’s undiscovered gems.  

As Algeria’s oil and gas revenues grew in the 1960s and 70s, successive governments lost interest in developing mass tourism. A descent into political strife in the 1990s pushed the country further off the beaten track.  

But while security is now much improved, Algeria needs to tackle an inflexible visa system and poor transport links, as well as grant privileges to local and foreign private investors to enable tourism to flourish, analysts say.  

Saliha Nacerbay, General Director of the National Tourism Office, outlined plans to attract 12 million tourists by 2030 – an ambitious fourfold increase.  

“To achieve this, we, as the tourism and traditional industry sector, are seeking to encourage investments, provide facilities to investors, build tourist and hotel facilities,” she said, speaking at the International Tourism and Travel Fair, hosted in Algiers from May 30 to June 2.  

Algeria has plans to build hotels and restructure and modernize existing ones. The tourism ministry said that about 2,000 tourism projects have been approved so far, 800 of which are currently under construction.  

The country is also restoring its historical sites, with 249 locations earmarked for tourism expansion. Approximately 70 sites have been prepared, and restoration plans are underway for 50 additional sites, officials said.  

French tourist Patrick Lebeau emphasized the need to improve infrastructure to fully realize Algeria’s tourism prospects.  

“Obviously, there is a lot of tourism potential, but much work still needs to be done to attract us,” Lebeau said.  

Tourism and travel provided 543,500 jobs in Algeria in 2021, according to the Statista website. In contrast, tourism professionals in Morocco estimate the sector provides 700,000 direct jobs in the kingdom, and many more jobs indirectly.

In Mexico’s Yucatan Peninsula, a hidden underground world is under threat by the Maya Train

AKTUN TUYUL CAVE SYSTEM, Mexico — Rays of sunlight slice through pools of crystal water as clusters of fish cast shadows on the limestone below. Arching over the emerald basin are walls of stalactites dripping down the cavern ceiling, which opens to a dense jungle.

These glowing sinkhole lakes — known as cenotes — are a part of one of Mexico’s natural wonders: A fragile system of an estimated 10,000 subterranean caverns, rivers and lakes that wind almost surreptitiously beneath Mexico’s southern Yucatan peninsula.

Now, construction of President Andrés Manuel López Obrador’s crown jewel project — the Maya Train — is rapidly destroying part of that hidden underground world, already under threat by development and mass tourism. As the caverns are thrust into the spotlight in the lead-up to the country’s presidential elections, scientists and environmentalists warn that the train will mean long-term environmental ruin.

Deep in the jungle, the roar of heavy machinery cuts through the cave’s gentle “drip, drip, drip.” Just a few meters above, construction of the train line is in full swing. The caverns rumble as government workers use massive metal drills that bore into limestone, embedding an estimated 15,000 steel pillars into the caverns.

Engineer Guillermo D’Christy looks upon the once immaculate cave, now coated with a layer of concrete and broken stalactites, icicle-shaped rock formations normally hanging from the roof of the cave. A mix of grief and anger is painted upon the face of D’Christy, who has long studied the waters running through the caves.

“Pouring concrete into a cavern, directly into the aquifer, without any concern or care,” D’Christy said. “That’s total ecocide.”

A tourism boon, but at what cost?

For nearly 1,460 kilometers, (1,000 miles) the high-speed Maya Train will wind its way around Mexico’s southern Yucatan Peninsula. When it’s completed, it’ll connect tourist hubs like Cancun and Playa del Carmen to dense jungle, remote communities and archaeological sites, drawing development and money into long-neglected rural swathes of the country.

The more than $30 billion train is among the keystone projects of Mexico’s outgoing President López Obrador, who has spent his six years in office portraying himself as a champion of the country’s long-forgotten poor.

“The Maya Train will be our legacy of development for the southeast of Mexico,” the president wrote in a post on the social platform X last year.

With Mexico holding elections on Sunday, the future of the train, and López Obrador’s legacy, is uncertain. Both leading candidates to replace him have made promises for a green agenda, but also supported the economic promises the train brings.

At issue is the path the train takes.

It was originally planned to run along the region’s highway in more urban areas. But after waves of complaints by hotel owners, the government moved one of the final sections of the line deeper into the jungle, atop the most important cave system in the country. It’s plowed down millions of trees, a chunk of the largest tropical forest in the Americas after the Amazon.

The caves contain one of the biggest aquifers in Mexico and act as the region’s main water source, crucial at a time when the nation faces a deepening water crisis. In 2022, archaeologists also discovered some of the oldest human remains in North America within the caverns.

The area was once a reef nestled beneath the Caribbean Sea but changing sea levels pushed Mexico’s southern peninsula out of the ocean as a mass of limestone. Water sculpted the porous stone into caves over millions of years.

It produced the open-face freshwater caverns, “cenotes,” and underground rivers that are in equal parts awe-inspiring and delicate, explained Emiliano Monroy-Ríos, a geologist at Northwestern University studying the region.

“These ecosystems are very, very fragile,” Monroy-Ríos said. “They are building upon a land that is like Gruyere cheese, full of caves and cavities of different sizes and at different depths.”

López Obrador promised his government would prevent damage to the Great Mayan Aquifer by elevating the sections of the train on thousands of hefty steel pillars buried deep into the ground.

But the populist leader was met with an uproar in late January when environmentalists and scientists posted videos showing government drills carving tunnels into the tops of caverns, implanting rows of 2-meter-wide (6-foot-wide) steel pillars.

López Obrador responded angrily to the videos, calling them “staged” by his political enemies.

“These pseudo-environmentalists are liars,” López Obrador said in a news briefing. “Don’t watch those videos because they’re specialists in staging.”

Associated Press journalists traveled to construction sites along the Maya Train route where López Obrador denied causing any environmental damage. What they saw directly contradicted the president’s claims.

Documenting destruction

D’Christy treks through dense rainforest and clicks on his headlight as he climbs into a split in a rock.

The engineer and hydrological expert has spent 25 years roving the intricate cave system, tracking the quality of the waters. Like many of the people studying the mysteries of the ancient cave system, his once tame job was inadvertently turned turbulent with the rise of the train project.

Today, he wanders into a small section of the caverns known as Aktun Tuyul, less than an hour from the tourist city of Playa del Carmen. As the 58-year-old Mexican walks past layers of stalactites and steel pillars burrowing into the rock formations, the cave’s darkness is broken by wagon wheel-sized holes drilled into the roof of the cave, where even more pillars will be implanted.

D’Christy wades through waist-deep water, now turned a murky brown by corroded metal from the pillars and pushes his body through a narrow passage in the rock.

Sitting next to one of more than a dozen pillars embedded into this cavern, he pulls out a series of syringes and bottles, taking a sample of the water next to the metal.

“It clearly has a color characteristic of iron contamination,” he said, holding up a syringe of foggy yellow water. “We’re going to take a sample.”

D’Christy pours the water into a glass vial, mixing it with a chemical that turns it a deep blue, indicating the water contains traces of iron from the poles. Next to other pillars, he presses his ear to the metal, listening to globs of concrete pour into the hollow tube.

Across the cave system, stalactites broken off by vibrations from train construction litter the ground like rubble following an earthquake. In other caverns, the concrete filling the pillars has spilled out to coat the limestone ground.

While the long-term environmental consequences of the construction are unknown, what is certain is that it is transforming the entire ecosystem, said geologist Monroy-Ríos.

“Just by drilling, before you even put in the pillars, you are killing an entire ecosystem that was in those caves” he said. “Why? Because now light is coming in, the gases within have changed, and there are very sensitive species that live in total darkness. They have already killed hundreds of millions” of organisms.

But the geologist’s greatest concern continues to be that the morphing limestone upon which the train is built and caves underneath the pillars could cause a collapse of the line. Scientists have long warned of the risks of building on soluble rock like limestone.

Already, sections of highway in the Yucatan have warped or caved in, and the Maya Train has been marred by a series of accidents, including a March train derailment, which government officials blamed on a loose clamp set by contractors.

Further damage to the limestone could lead to another accident that could be deadly. If a cargo train derailed, it could cause an oil spill that could permanently devastate the aquifer, Monroy-Ríos said.

‘It will benefit us all’

Not everyone is opposed to the train running through the remote communities. Some see an unprecedented economic opportunity, a chance to help poor families earn money.

Maria Norma de los Angeles and her family have long lived off a modest flow of tourists in their community of Jacinto Pat, tucked in a stretch of jungle in the southern coastal state, Quintana Roo.

They offer temazcal baths, traditional Mayan steam rooms meant to purify and relax the body, and charge visiting foreigners to swim in a nearby cenote.

The family, like many along the train’s path, was originally opposed to the project because they worried it would destroy the cenotes drawing tourists.

But their feelings about the train began to change when government officials contracted local people to build the track, De los Angeles said. They also promised to bring communities electricity, a sewage system and running water, and agreed to pay more for the land the train would pass over.

“It has its pros and its cons,” De los Angeles said as her family gathered to kill a pig to eat for her father’s birthday. “But there will be a moment when we see an economic spillover … I know that it will benefit us all.”

That’s the mentality of many Mexicans toward both the train and López Obrador. Many are willing to overlook the controversies of the populist and his train, in favor of his charisma and the strong economy seen during his presidency.

The 70-year-old leader has connected with Mexico’s long-invisible working class in a way few leaders have in recent history. López Obrador’s government has raised the minimum wage and provided cash handouts to older Mexicans and students. The government says more than 5 million people have been pulled out of poverty while López Obrador was president.

Luruama de la Cruz, a California resident whose family comes from the local town of Leona Vicario, said she bought her father tickets to the train for his birthday because it was a dream of his.

“A dream made reality,” De la Cruz says as she rode the train and took a video on her phone, meandering past passengers wearing “Maya Train” T-shirts and watching an interview between López Obrador and Russian state media.

“Whenever you build something, something else is destroyed,” she said, adding that family members worked on train construction. “This is for the good of the people.”

A rush to build the track

López Obrador has fast-tracked construction of the train to try to keep promises to complete it before June elections, something that has appeared all but impossible. The moves he’s made have only deepened his ongoing clashes with the country’s judiciary, further fueling criticisms that his government is undermining democratic institutions.

In a violation of Mexican law, the government didn’t carry out a comprehensive study to assess the potential environmental impacts before starting construction. That’s led to blindly plowing into caverns with no clue what’s being damaged, scientists and independent lawyers say.

“Our president has little respect for the law. He’s in a sort of tug of war for power and he does what he wants,” said Claudia Aguilar, a lawyer at Mexico’s Free School of Law.

When a judge ordered construction of the line be suspended until an adequate report of how the train would affect the caves was carried out, López Obrador ignored the ruling, and the work continued.

At the same time, much of the project has been cloaked in secrecy as López Obrador has charged Mexico’s military with construction and blocked the release of information in the name of “national security.”

While Mexico’s Supreme Court ruled that unconstitutional, López Obrador disregarded that ruling, too, saying it was to protect his project from “corrupt” critics.

When the AP requested an interview with leadership of the Maya Train project, spokesperson Mariana Galicia said they were “ordered that we cannot give interviews” but could respond to questions sent over email to “better control” the information shared. They did not respond to questions sent by email.

‘Swimming in poop’

Meanwhile, thousands of passengers are already riding sections of the train that have been built. The atmosphere above is far-removed from the conflicts playing out around the caverns.

Hotels and clubs host raves and even music festivals in some of the cenotes, with one club boasting it “takes the relaxation and wellness experience to another level. Let yourself be enveloped by this sacred, timeless place.”

Luxurious beach hotels and booming clubs packed with drunk, khaki-clad tourists dominate the coastal tourist city of Playa del Carmen. Once a Mayan settlement, the city is among many in the Yucatan Peninsula that in recent decades have been converted into a party hub for vacationing foreigners.

In the caves below, biologist Roberto Rojo paddles through a sea of trash.

Under the arching cavern roof, Rojo and a group of volunteers push a green kayak through a cenote, filling bulking bags of glass beer bottles, plastic tubes, metal grating, plastic Coca-Cola bottles, rotten wooden planks and even a printer.

“You don’t even want to know what many of those things are,” Rojo said.

It’s a fate Rojo and many others worry may await hundreds of cenotes, caves and underground lakes and rivers along the new Maya Train line.

“It’s not just the train, but everything the train brings with it – urban developments, hotel developments,” said water expert D’Christy. “Rather than solving a problem, they’re coming in and making a big problem worse.”

Millions of tourists a year flock to the region, affecting the entire underground as the industry guzzles water and sewage seeps through the earth and into the caves, killing fish and other wildlife. In 2022, authorities found that the water of more than a dozen of the caverns near the tourist city of Tulum was tainted with E. Coli bacteria.

Last year, the environmental organization Va Por La Tierra estimated that approximately 95% of the cenotes in Yucatan state — where the Maya Train cuts through — were already contaminated due to the lack of a sufficient sewage system. Scuba diving master Bernardette Carrión even told the AP that tourists admiring the splendor of the caves “are swimming in poop.”

The underground system is connected to the sea, so waste trickles out to the ocean, where scientists say it feeds seaweed-like algae piling up on Caribbean coastlines, spurring on a slate of other environmental and health hazards.

Rojo and other volunteers created the organization known as “Urban Cenotes” in Playa del Carmen to clean the water system, cave by cave.

“We’re trying to return the dignity that these spaces have had for thousands of years, that are now being turned into landfills, sewers and drains,” Rojo said.

But it’s an uphill battle for the hundreds of volunteers, and something they worry will become impossible as pollution expands into rural areas with the Maya Train, deepening ongoing pollution caused by pig farms and massive soy plantations.

Looking forward, they’re uncertain about what will come as June elections ended Sunday night, with López Obrador leaving office in the coming months. The leader will likely be replaced by either race front-runner and ally Claudia Sheinbaum or rival ex-Senator Xóchitl Gálvez.

Sheinbaum, an environmental scientist who leads the race by a comfortable margin, has portrayed herself as a champion for the environment, but has supported López Obrador’s fossil-fuel agenda and made few remarks about the environmental damage the train has wrought.

Little more than a week before Sunday’s presidential election, Sheinbaum said she was meeting with leaders of neighboring Guatemala and Belize in talks to extend the Maya Train to Central America.

Gálvez, a López Obrador opponent, has taken advantage of the controversy to tear into her adversaries, calling the train’s damage “irreversible” and a “consequence of the negligence of the government because they didn’t do any environmental impact studies.” Months earlier, though, she said she would also continue with plans to extend the train.

Meanwhile, groups like Rojo’s do everything they can to salvage an ecosystem that took millennia to form. They worry they might not have all that much time left.

“I’m not going to sit quietly and wait for the government to solve things,” Rojo said. “The people who live in the Yucatan peninsula are on the verge of a water crisis.”

Next Boeing CEO should understand past mistakes, airlines boss says 

DUBAI — The next CEO of Boeing BA.N should have an understanding of what led to its current crisis and be prepared to look outside for examples of best industrial practices, the head of the International Air Transport Association said on Sunday.

U.S. planemaker Boeing is engulfed in a sprawling safety crisis, exacerbated by a January mid-air panel blowout on a near new 737 MAX plane. CEO Dave Calhoun is due to leave the company by the end of the year as part of a broader management shake-up, but Boeing has not yet named a replacement.

“It is not for me to say who should be running Boeing. But I think an understanding of what went wrong in the past, that’s very important,” IATA Director General Willie Walsh told Reuters TV at an airlines conference in Dubai, adding that Boeing was taking the right steps.

IATA represents more than 300 airlines or around 80% of global traffic.

“Our industry benefits from learning from mistakes, and sharing that learning with everybody,” he said, adding that this process should include “an acknowledgement of what went wrong, looking at best practice, looking at what others do.”

He said it was critical that the industry has a culture “where people feel secure in putting their hands up and saying things aren’t working the way they should do.”

Boeing is facing investigations by U.S. regulators, possible prosecution for past actions and slumping production of its strongest-selling jet, the 737 MAX.

‘Right steps’

Calhoun, a Boeing board member since 2009 and former GE executive, was brought in as CEO in 2020 to help turn the planemaker around following two fatal crashes involving the MAX, its strongest-selling jet.

But the planemaker has lost market share to competitor Airbus AIR.PA, with its stock losing nearly 32% of its value this year as MAX production plummeted this spring.

“The industry is frustrated by the problems as a result of the issues that Boeing have encountered. But personally, I’m pleased to see that they are taking the right steps,” Walsh said.

Delays in the delivery of new jets from both Boeing and Airbus are part of wider problems in the aerospace supply chain and aircraft maintenance industry complicating airline growth plans.

Walsh said supply chain problems are not easing as fast as airlines want and could last into 2025 or 2026.

“It’s probably a positive that it’s not getting worse, but I think it’s going to be a feature of the industry for a couple of years to come,” he said.

Earlier this year IATA brought together a number of airlines and manufacturers to discuss ways to ease the situation, Walsh said.

“We’re trying to ensure that there’s an open dialogue and honesty,” between them, he said.

Extreme heat: Climate change’s silent killer

Geneva — Nearly 62,000 people died from heat-related stress in the summer of 2022 in Europe alone, and, according to a new study by the Intergovernmental Panel on Climate Change, or IPCC, “With further global warming, we can expect an increase in the intensity, frequency, and duration of heatwaves.”

The report launched ahead of Heat Action Day on Sunday, June 2, looks at the role climate change is playing in increasing the number of extreme heat days around the world over the last 12 months.

“What we are now going through is a very silent but increasingly common killer — heat, that was particularly disastrous last year,” said climatologist Friederike Otto, co-lead of World Weather Attribution at Imperial College London and one of the authors of the report.

Speaking from London last Tuesday, she told journalists in Geneva that this May was hotter than any May ever experienced before, as were all months for the past 12 months.

“Every heat wave that is happening today is hotter and lasts longer than it would have without human-induced climate change. That is without the burning of coal, oil and gas and we also see many more heat waves than we have otherwise,” she said noting that temperatures right now were around 50° C (122° F) in India and Pakistan.

The World Meteorological Organization confirms that 2023 was the hottest year on record, reaching 1.45° C (2.6° F) above the pre-industrial average, almost reaching the Paris Climate Agreement to limit global warming to 1.5° C.

According to the report, the average inhabitant of the planet has experienced 26 more extremely hot days, “which probably would not have occurred without climate change.” Or put another way, 6.8 billion people —78 percent of world’s population — have experienced at least 31 days of extreme heat.

“But, of course, we are not average people. We live in a specific place, in a specific country,” said Otto. “So, for example if you lived in Ecuador, it was not 26 more days, but it was 170 more days. In other words, in the last 12 months, the people in Ecuador experienced 180 days of extreme heat. Without climate change, it would have been just 10. So, it is six months of extreme heat, instead of 10 days.”

She noted that extreme heat was dangerous and responsible for thousands of deaths every year. She said, “Heat harmed especially vulnerable people: the elderly, the very young, those with pre-existing health conditions” as well as healthy people exposed to extreme temperatures, “like outdoor workers in construction or agriculture and people living in refugee camps.”

The World Health Organization, previewing a new collection of papers to be published this week in the Journal of Global Health, says the studies show “climate-related health risks have been crucially underestimated” for younger and older people and during pregnancy, “with serious, often life-threatening implications.”

Taking extreme heat for example, WHO says the authors note that preterm births — the leading cause of childhood deaths, “spike during heatwaves, while older people are more likely to suffer heart attacks or respiratory distress.”

Heat Action Day, which is organized by the Red Cross Red Crescent Climate Center, aims to draw attention to the threat of extreme heat and to what can be done to mitigate it.

In a statement to mark Heat Action Day, Jagan Chapagain, secretary-general of the International Federation of Red Cross and Red Crescent Societies, said, “Flooding and hurricanes may capture the headlines, but the impacts of extreme heat are equally deadly.

“That is why Heat Action Day matters so much,” he said. “We need to focus attention on climate change’s silent killer. The IFRC is making heat and urban action to reduce its impacts a priority.”

Climatologist Otto said the burning of fossil fuels must stop to prevent the situation from becoming worse.

“Heat kills. But it does not have to kill. There are many solutions, some of which are low or no cost, ranging from individual action to population-scale interventions that reduce the urban heat island effect.

“At an individual level, people can cool their bodies by self-dousing with water, using cooling devices or modifying their built environment to increase shade” around their homes.

But she observed that individual action alone is not enough. She said action had to be taken at the community, city, regional and country levels as well.

“Cities can develop and implement heat action plans that outline how they will prepare for the heat season, respond to imminent heat waves, and plan for the future.

“And on a large scale, policies can be introduced to incorporate cooling needs into social protection programs, supplement energy costs for the most vulnerable and building codes can be updated to encourage better housing,” she said.

Nigeria’s new anthem, written by a Briton, sparks criticism

ABUJA, Nigeria — Nigeria adopted a new national anthem Wednesday after lawmakers passed a law that replaced the current one with a version dropped nearly a half-century ago, sparking widespread criticism about how the law was hastily passed without much public input.

President Bola Tinubu’s assent to the law comes a day after it was approved by both chambers of Nigeria’s National Assembly, which is dominated by the governing party. The federal lawmakers introduced and passed the bill in less than a week, an unusually fast process for important bills that usually take weeks or months to be considered.

The Arise, O Compatriots anthem being replaced had been in use since 1978, when it was introduced by the military government. The anthem was composed at a time when the country was reeling from a deadly civil war and calls on Nigerians to “serve our fatherland with love and strength” and not to let “the labor of our heroes past (to be) in vain.”

The new version that takes immediate effect was first introduced in 1960 when Nigeria gained independence from Britain before it was dropped by the military. Titled Nigeria We Hail Thee, it was written by Lillian Jean Williams, a British expatriate who was living in Nigeria at the time.

The new anthem was played publicly for the first time at a legislative session attended by Tinubu, who marked his one year in office as president Wednesday.

Many Nigerians, however, took to social media to say they won’t be singing the new national anthem, among them Oby Ezekwesili, a former education minister and presidential aspirant who said that the new law shows that the country’s political class doesn’t care about the public interest.

“In a 21st Century Nigeria, the country’s political class found a colonial National Anthem that has pejorative words like “Native Land” and “Tribes” to be admirable enough to foist on our Citizens without their consent,” Ezekwesili posted on X.

Supporters of the new anthem, however, argued it was wrong for the country to have adopted an anthem introduced by the military.

“Anthems are ideological recitations that help the people to be more focused. It was a very sad development for the military to have changed the anthem,” public affairs analyst Frank Tietie said.