‘Reprogrammed’ Stem Cells Fight Parkinson’s Disease in Monkeys

Scientists have successfully used “reprogrammed” stem cells to restore functioning brain cells in monkeys, raising hopes the technique could be used in the future to help patients with Parkinson’s disease.

Since Parkinson’s is caused by a lack of dopamine made by brain cells, researchers have long hoped to use stem cells to restore normal production of the neurotransmitter chemical.

Now, for the first time, Japanese researchers have shown that human induced pluripotent stem cells (iPS) can be administered safely and effectively to treat primates with symptoms of the debilitating disease.

So-called iPS cells are made by removing mature cells from an individual — often from the skin — and reprogramming them to behave like embryonic stem cells. They can then be coaxed into dopamine-producing brain cells.

The scientists from Kyoto University, a world-leader in iPS technology, said their experiment indicated that this approach could potentially be used for the clinical treatment of human patients with Parkinson’s.

In addition to boosting dopamine production, the tests showed improved movement in affected monkeys and no tumors in their brains for at least two years.

The human iPS cells used in the experiment worked whether they came from healthy individuals or Parkinson’s disease patients, the Japanese team reported in the journal Nature on Wednesday.

“This is extremely promising research demonstrating that a safe and highly effective cell therapy for Parkinson’s can be produced in the lab,” said Tilo Kunath of the MRC Center for Regenerative Medicine, University of Edinburgh, who was not involved in the research.

The next step will be to test the treatment in a first-in-human clinical trial, which Jun Takahashi of Kyoto University told Reuters he hoped to start by the end of 2018.

Any widespread use of the new therapy is still many years away, but the research has significantly reduced previous uncertainties about iPS-derived cell grafts.

The fact that this research uses iPS cells rather human embryonic stem cells means the treatment would be acceptable in countries such as Ireland and much of Latin America, where embryonic cells are banned.

Excitement about the promise of stem cells has led to hundreds of medical centers springing up around the world claiming to be able to repair damaged tissue in conditions such as multiple sclerosis and Parkinson’s.

While some treatments for cancer and skin grafts have been approved by regulators, many other potential therapies are only in early-stage development, prompting a warning last month by health experts about the dangers of “stem-cell tourism.”

Dream Chaser Spacecraft in Captive-carry Test Over Desert

A test version of a spacecraft resembling a mini space shuttle was carried aloft over the Mojave Desert by a helicopter Wednesday in a precursor to a free flight in which it will be released to autonomously land on a runway as it would in a return from orbit.

 

Sierra Nevada Corp.’s Dream Chaser craft was lifted off the ground at 7:21 a.m., at NASA’s Armstrong Flight Research Center on Edwards Air Force Base, California, and was carried to the same altitude and flight conditions it will experience before release in a free flight.

 

A control team sent commands to the wingless vehicle and collected data before the helicopter brought it down at 9:02 a.m., the company said.

 

“Everything we have seen points to a successful test with useful data for the next round of testing,” director of flight operations Lee “Bru” Archambault said in a statement.

 

A second captive-carry test is scheduled this year and if it is successful, a free flight test will follow.

 

The Dream Chaser is being developed to carry cargo to and from the International Space Station without a crew aboard. The version flown Wednesday is for tests in the atmosphere. The version that will be launched into space is still in development.

 

With the addition of life-support equipment, a Dream Chaser could transport a crew of seven.

 

Last month, Sierra Nevada selected United Launch Alliance’s Atlas 5 rocket to launch the first two Dream Chaser cargo missions, which are scheduled to blast off from Cape Canaveral, Florida, in 2020 and 2021. Those missions will land at Kennedy Space Center.

 

The Dream Chaser is a type of craft known as a “lifting body” in which aerodynamic lift is generated by its shape rather than wings like those of a conventional aircraft. Tail fins angling upward at the rear of the craft provide control.

 

NASA proved the lifting body concept by flying a series of wingless aircraft at Edwards in the 1960s and ’70s.

 

The Dream Chaser is 30 feet (9 meters) long, about one quarter the length of a space shuttle.

 

Sierra Nevada is headquartered in Sparks, Nevada, and the Dream Chaser is being developed by the company’s Louisville, Colorado-based Space Systems business.

Famed T. rex ‘Sue’ Will Get New Look at Chicago’s Field Museum

The world’s biggest T. rex is getting ready for a cutting-edge makeover.

The Field Museum in Chicago said Wednesday that it would take down and remount the 40½-foot-long (12.3-meter) Tyrannosaurus nicknamed Sue, perhaps the world’s most famous dinosaur fossil, in a way that embodies the latest understanding of this ferocious Cretaceous Period predator.

The big T. rex will move to a new exhibition space in the museum, while a cast of the skeleton of the largest-known dinosaur, Patagotitan mayorum, will take the spot Sue now occupies in the museum’s Stanley Field Hall.

Patagotitan, a long-necked, four-legged plant-eater that was 122 feet (37.2 meters) long and weighed 70 tons, lived in Argentina 100 million years ago, more than 30 million years before T. rex stalked western North America. The biggest land animal on record, it was a member of a dinosaur group called titanosaurs.

The museum next spring will unveil the fiberglass Patagotitan skeleton, which is being cast from fossils of seven Patagotitan individuals, and for two years will display some of the genuine fossils, including an 8-foot (2.4-meter) thighbone.

Named for the woman who discovered the fossils in South Dakota in 1990, Sue is the largest, most complete and best-preserved Tyrannosaurus rex ever unearthed. The museum bought the fossils at auction for $8.4 million.

Sue will be taken down in February and put up again with noteworthy changes in anatomy and stance in its new exhibition hall in spring 2019, museum scientists said.

“We are making several adjustments to the skeleton to reflect new and improved knowledge,” said paleontologist Pete Makovicky, the museum’s associate curator of dinosaurs.

The most striking change, Makovicky said, will be the addition of gastralia, bones resembling an additional set of ribs spanning the belly that may have provided structural support to help the dinosaur breathe. Adding these bones will illustrate just how massive Sue was and that it boasted a bulging belly, he added.

The scientists concluded that the bone mounted as Sue’s wishbone was misidentified in 2000, and they will replace it with the dinosaur’s actual wishbone, or furcula, the fused collarbones typical of meat-eating dinosaurs and their evolutionary descendants, the birds.

They also will adjust the ribs to produce a slimmer, less barrel-shaped chest and arrange the right leg so Sue is not crouching as much.

“Often when you do something as expensive as mounting a vertebrate fossil skeleton for display, you only get one shot at it. I’m happy we’re going to fix and update this incredible fossil,” said paleontologist Bill Simpson, who heads the museum’s geological collections.

Lifespan and bite force

Makovicky noted the accumulation of knowledge about T. rex and its cousins since 2000.

“We now know more about tyrannosaur lifespans — around 30 years; how they grew — very fast as teenagers; and using computer models of Sue, we revised their body mass upward to 9 or more tons, from 5 to 7 tons,” Makovicky said.

Ongoing research is examining the molecular composition of cartilage preserved in T. rex bones, and recent studies have shown it possessed the most powerful bite of any land animal ever, Makovicky added.

When the Patagotitan skeleton is mounted, visitors will be able to walk underneath it and touch it. Its head will reach the museum’s second-floor balcony nearly 30 feet (9 meters) up.

Another Patagotitan skeleton is displayed at the American Museum of Natural History in New York.

The museum said a $16.5 million gift from the Kenneth C. Griffin Charitable Fund, established by the founder and chief executive of hedge fund firm Citadel LLC, enabled it to carry out Sue’s makeover and add the Patagotitan. The changes coincide with the museum’s 125th anniversary in 2018.

Alexa, Cortana Talk to Each Other in Amazon-Microsoft Deal

Microsoft and Amazon are pairing their voice assistants together in a collaboration announced Wednesday.

Both companies say later this fall, users will be able to access Alexa using Cortana on Windows 10 computers and on Android and Apple devices. They’ll also be able to access Cortana on Alexa-enabled devices such as the Amazon Echo.

Microsoft says the tie-up will allow Alexa customers to get access to Cortana features such as for booking meetings or accessing work calendars. Cortana users, in turn, can ask Alexa to switch on smart home devices or shop on Amazon’s website.

The use of voice assistants is growing. Google and Amazon already have smart speakers on the market. Apple has HomePod coming with its Siri assistant, while Samsung plans one with Microsoft’s Cortana.

Amazon has little to lose from the partnership, and Microsoft’s Cortana — which has been largely limited to laptops — might get discovered by more users because of it, said Carolina Milanesi, a mobile technology analyst at Creative Strategies.

“Cortana might get a little bit more out of it because it gets Cortana out of the PC,” she said. “For Cortana to really get to be more important, it needs to be consistently used every day for different tasks.”

Milanesi said that for Amazon especially, which wants more people to consider Alexa as their first choice, the partnership also might be designed to send a message to customers and rivals.

“They both get something out of it, which is mainly showing Apple and Google that they’re willing to work together to get stronger,” Milanesi said.

US Economic Growth Upgraded to 3 Percent Rate in Q2

The U.S. economy rebounded sharply in the spring, growing at the fastest pace in more than two years amid brisk consumer spending on autos and other goods.

 

The gross domestic product, the broadest measure of economic health, grew at an annual rate of 3 percent in the April-June quarter, the Commerce Department reported Wednesday. It was the best showing since a 3.2 percent gain in the first quarter of 2015.

 

The result is a healthy upward revision from the government’s initial estimate of 2.6 percent growth in the second quarter. The growth rate in the January-March quarter was a lackluster 1.2 percent.

 

Improvements in consumer spending, particularly on autos, and business investment powered second-quarter growth. Those revisions offset a bigger drag from spending by state and local governments.

This was the second of three estimates the government will provide for second quarter growth. Even with the upward revision, the weak start to the year means that growth over the past six months has averaged 2.1 percent, the same modest pace seen for the recovery that began in mid-2009.

 

During last year’s presidential campaign, Donald Trump attacked the Obama administration’s economic record, pledging to double GDP growth to 4 percent or better. His first budget, sent to Congress earlier this year, projects growth rates will climb to a sustained annual rate of 3 percent, a goal that many private economists believe is still too optimistic.

 The nonpartisan Congressional Budget Office sees growth averaging 1.9 percent over the next decade, a forecast much closer to estimates made by private economists.

 

Many economists had been forecasting growth in the current July-September quarter would be around 3 percent. Some are now saying that the devastation from Hurricane Harvey could shave about a half-percentage point off growth this quarter. However, analysts believe the pace of growth will bounce back once the rebuilding begins and oil refineries get back to full production, bringing down prices.

For the entire year, Mark Zandi, chief economist at Moody’s Analytics, is forecasting growth of 2.1 percent. That would mark an improvement over last year when the economy grew a meager 1.5 percent, the poorest showing since 2009 when GDP shrank by 2.9 percent.

Zandi is forecasting that growth in 2018 will be an even stronger 2.8 percent. But he said 0.4 percentage point of that forecast reflects an assumption that the Trump administration will win a tax cut package that will take effect in early 2018. The economy will also be boosted by higher spending on the military and infrastructure projects, he said.

 

“For the first time since the Great Recession ended in mid-2009, the economy is not facing any significant headwinds,” Zandi said.

 

 

Source: US Sanctions on Venezuela Oil Company CFO Tangle Financial Deals

U.S. sanctions on the finance boss of Venezuela’s oil company PDVSA have led to some exports to the United States being blocked as banks and investment funds refuse to provide letters of credit to potential buyers, three financial sources said.

U.S. businesses are barred from dealing with a sanctioned person or company and one of the sources said the sanctions on PDVSA’s Finance Vice President Simon Zerpa were deterring some businesses from investments with the company as so many of its transactions are linked to the finance department he leads.

A Venezuelan oil shipment to the United States was blocked this month as lenders refused to provide letters of credit to PDVSA customers, the sources said.

Letters of credit, issued by banks, guarantee to a seller that a buyer will pay a specified amount on time when a shipment is accepted. Without a letter of credit, shipments cannot be delivered and the shipper does not get paid. Blocking letters of credit for PDVSA oil chokes off cash that is desperately needed in the OPEC nation.

Petróleos de Venezuela, S.A., commonly known as PDVSA, is the financial motor of President Nicolas Maduro’s leftist government, and it is operating within one of the deepest economic recessions Venezuela has ever experienced and widespread political unrest.

In one instance, U.S. refiner PBF Energy was unable to get a letter of credit for a Venezuelan crude cargo to be received at a U.S. port.

The Suezmax tanker Karvounis has been anchored in the U.S. Gulf for more than a month. It partially discharged its cargo on Aug. 23 in New Orleans, according to Thomson Reuters vessel tracking data. A trader close to the deal said PBF Energy ultimately agreed to a prepayment, removing the need for a credit letter. It was unclear what would happen with the rest of the cargo.

Some U.S. customers can import without a letter of credit if they pay up front.

In July, the United States imposed sanctions on 13 senior Venezuelan officials, including the head of Venezuela’s army, the national police chief, the director of elections, and Zerpa.

At the time, a U.S. official warned that the administration of U.S. President Donald Trump was readying tougher measures that could be part of a “steady drumbeat” of responses to the Venezuelan crisis.

The most serious potential future step would be financial sanctions that would halt dollar payments for the country’ oil, starving the government of hard currency, or a total ban on oil imports to the United States, Venezuela’s biggest customer.

This month the United States imposed its first economic sanctions on Venezuela, banning debt trades for government-issued bonds and bonds issued by PDVSA. 

The problem could spread to more cargoes if banks refuse to extend credit to companies that have a commercial relationship with PDVSA, the sources said.

The sources said foreign oil companies funding projects in Venezuela and financial entities negotiating with PDVSA were avoiding signing agreements that could involve Zerpa.

Major oil company China National Petroleum Corporation (CNPC) has pulled back from funding some operations at its joint venture in Venezuela, a source at PDVSA said.

Neither PDVSA nor the Information Ministry responded to requests for comment. Zerpa was not immediately available to comment.

“PDVSA will face additional trouble just by keeping a sanctioned individual as CFO,” said Jorge Piedrahita, chief executive of broker-dealer Gear Capital Partners, who has been involved with Venezuelan debt for many years.

“Even the Russians and China’s Development Bank should be worried about signing something with him as they can be subject to collateral damage from sanctions just by association.”

A close Maduro ally, Zerpa, 34, rose to prominence by leading the bilateral Venezuela-China fund through which Caracas borrows from Beijing and repays loans in oil and fuel. Venezuela has borrowed over $60 billion from China, earning Zerpa the nickname “Zerpa the Chinese.”

Two additional financial sources said having Zerpa as the company’s head of finance had made it impossible for U.S. entities to assist PDVSA in debt refinancing, even before the U.S. economic sanctions.

Even basic activities, such as a conference call with bondholders, are now essentially unthinkable, the sources said.

Sanctions against Zerpa are having a knock-on effect on Wall Street, affecting imports of food and medicine to Venezuela made through funds headed by Zerpa, according to Delcy Rodriguez, president of Maduro’s new legislative assembly.

“This wasn’t done to affect Venezuelan officials but rather the entire population,” Rodriguez said on Monday.

Zerpa has held several high-profile posts including heading Venezuela’s state economic development bank Bandes and off-budget investment fund Fonden.

Opposition lawmakers have said he is an example of how the late Hugo Chavez’s “21st century socialism” has allowed unprepared political figures to wield power over financial deals.

“I have a negative opinion of him because of the way he handled the Chinese fund,” said opposition lawmaker Angel Alvarado, describing Zerpa as Maduro’s “finance tsar.”

U.S. pressure could force PDVSA to remove Zerpa from his post, at least on paper. However, PDVSA has had issues in the past that have led investors to tread cautiously with Venezuela.

“In part, the sanctions codify an already existing situation in which PDVSA and the Republic have little to no access to international financial markets due to the combination of political risk, unsustainable policies, concerns about legality

of new issues and reputational risk from providing funds to the Venezuelan government,” investment firm Torino Capital wrote in a report to clients after Friday’s sanctions.

Trump to Promote Tax Reform

U.S. President Donald Trump is traveling to the state of Missouri to try to build support for his goal of reforming the country’s tax code.

Administration officials say the president will focus on explaining the need for tax reform, but not the specifics of a plan to do so, during a speech Wednesday in the city of Springfield.  They say he will promote tax cuts as a way to help American workers.

Trump has in the past proposed cutting the corporate tax rate from 35 percent to 15 percent.

The U.S. tax code has not undergone a significant overhaul since 1986.

Trump’s Republican Party controls both houses of the U.S. Congress, but failed in its earlier efforts to overhaul another major program as leaders were unable to get enough votes to change the health care system.

Study: Cities and Companies Team Up to Tackle Urban Water Crises

With rising urban populations and ever scarcer water supplies, cities and companies are teaming up to invest billions of dollars in water management projects, a report said on Tuesday.

Around two thirds of cities from London to Los Angeles are working with the private sector to address water and climate change stresses with 80 cities seeking $9.5 billion of investment for water projects, according to a report by the Carbon Disclosure Project (CDP), a non-profit environmental research group.

Water investment opportunities are greatest in Latin America, with Quito in Ecuador seeking $800 million to manage its water supply, including building three hydropower stations and cleaning up its contaminated rivers and streams.

City in India prepares for future

The cities most concerned about their water supply lie in Asia and the Pacific, the report found, with serious risks also identified in Africa and Latin America.

The key issues for cities include declining water quality, water shortages and flooding.

The Indian city of Chennai faced extreme floods in 2015 which killed hundreds and left survivors without access to clean water, while businesses were also severely disrupted.

The city is now investing in boosting its resilience to future water crises, with water conservation education, building a storm water management system and new infrastructure.

“We are seeing critical shifts in leadership from cities and companies in response to the very real threat of flooding, for example, to local economies,” said Morgan Gillespy, head of CDP’s Water Program.

Climate change is another underlying threat to all cities with an increase in extreme weather events from droughts to floods, with cities in North America more concerned than those in Europe, the report found.

Tropical Storm Harvey, pounding the U.S. Gulf Coast, has killed at least eight people, led to mass evacuations and paralyzed Houston, the fourth most-populous U.S. city.

The storm is most likely linked to climate change, said the U.N. weather agency.

Companies are also concerned about the effects of climate change on water supplies, with $14 billion of water impacts such as loss of production reported by companies last year, the report found.

WATCH: Worrying About Water

UN predicts global water shortfall

The United Nations predicts a 40 percent shortfall in global water supply by 2030, while global demand is set to increase by 55 percent due to growing domestic use, manufacturing and electricity generation.

“From our work with cities around the world, water has consistently come up as a key resilience challenge,” said Claire Bonham-Carter, Principal and City Resilience Lead at AECOM, a global infrastructure firm and partner on the report.

“Many of them, regardless of size, from Mexico City, Mexico to Berkeley, California, are addressing both long-term water supply issues as well as chronic urban flooding.”

World’s Biggest Drone Drug Deliveries Take Off in Tanzania

Tanzania is set to launch the world’s largest drone delivery network in January, with drones parachuting blood and medicines out of the skies to save lives.

California’s Zipline will make 2,000 deliveries a day to more than 1,000 health facilities across the east African country, including blood, vaccines and malaria and AIDS drugs, following the success of a smaller project in nearby Rwanda.

“It’s the right move,” Lilian Mvule, 51, said by phone, recalling how her granddaughter died from malaria two years ago.

“She needed urgent blood transfusion from a group O, which was not available,” she told the Thomson Reuters Foundation.

Malaria is a major killer in Tanzania, and children under age 5 often need blood transfusions when they develop malaria-induced anemia. If supplies are out of stock, as is often the case with rare blood types, they can die.

Tanzania is larger than Nigeria and four times the size of the United Kingdom, making it hard for the cash-strapped government to ensure all of its 5,000-plus clinics are fully stocked, particularly in remote rural areas.

The drones fly at 100 kph (62 mph), much faster than traveling by road. Small packages are dropped from the sky using a biodegradable parachute.

The government also hopes to save the lives of thousands of women who die from profuse bleeding after giving birth.

Tanzania has one of the world’s worst maternal mortality rates, with 556 deaths per 100,000 deliveries, government data show.

“It’s a problem we can help solve with on-demand drone delivery,” Zipline’s chief executive, Keller Rinaudo, said in a statement. “African nations are showing the world how it’s done.”

Companies in the United States and elsewhere are keen to use drones to cut delivery times and costs, but there are hurdles ranging from the risk of collisions with airplanes to ensuring battery safety and longevity.

The drones will cut the drug delivery bill for Tanzania’s capital, Dodoma, one of two regions where the project will first roll out, by $58,000 a year, according to Britain’s Department for International Development, one of the project’s backers.

The initiative could also ease tensions between frustrated patients and health workers.

“We always accuse nurses of stealing drugs,” said Angela Kitebi, who lives 40 kilometers east of Dodoma. “We don’t realize that the drugs are not getting here on time due to bad roads.”

Are Consumers Ready to Give Augmented Reality a Try?

You might have gotten a taste of “augmented reality,” the blending of the virtual and physical worlds, as you chased on-screen monsters at real-world landmarks in last year’s gaming sensation, “Pokemon Go.”

Upcoming augmented reality apps will follow that same principle of superimposing virtual images over real-life settings. That could let you see how furniture will look in your real living room before you buy it, for instance.

While “Pokemon Go” didn’t require special hardware or software, more advanced AR apps will. Google and Apple are both developing technology to enable that. Google’s AR technology is already on Android phones from Lenovo and Asus. On Tuesday, Google announced plans to bring AR to even more phones, including Samsung’s popular S8 and Google’s own Pixel, though it didn’t give a timetable beyond promising an update by the end of the year.

As a result, Apple might pull ahead as it extends AR to all recent iPhones and iPads in a software update expected next month, iOS 11. Hundreds of millions of AR-ready devices will suddenly be in the hands of consumers.

But how many are ready to give AR a try?

Early applications

Of the dozen or so apps demoed recently for Android and iPhones, the ones showing the most promise are furniture apps.

From a catalog or a website, it’s hard to tell whether a sofa or a bed will actually fit in your room. Even if it fits, will it be far enough from other pieces of furniture for someone to walk through?

With AR, you can go to your living room or bedroom and add an item you’re thinking of buying. The phone maps out the dimensions of your room and scales the virtual item automatically; there’s no need to pull out a tape measure. The online furnishing store Wayfair has the WayfairView for Android phones, while Ikea is coming out with one for Apple devices. Wayfair says it’s exploring bringing the app to iPhones and iPads, too.

As for whimsical, Holo for Android lets you pose next to virtual tigers and cartoon characters. For iPhones and iPads, the Food Network will let you add frosting and sprinkles to virtual cupcakes. You can also add balloons and eyes — who does that? — and share creations on social media.

Games and education are also popular categories. On Apple devices, a companion to AMC’s “The Walking Dead” creates zombies alongside real people for you to shoot. On Android, apps being built for classrooms will let students explore the solar system, volcanoes and more.

Beyond virtual reality

Virtual reality is a technology that immerses you in a different world, rather than trying to supplement the real world with virtual images, as AR does. VR was supposed to be the next big thing, but the appeal has been limited outside of games and industrial applications. You need special headsets, which might make you dizzy if you wear one too long.

And VR isn’t very social. Put on the headset, and you shut out everyone else around you. Part of the appeal of “Pokemon Go” was the ability to run into strangers who were also playing. Augmented reality can be a shared experience, as friends look on the phone screen with you.

Being available vs. Being used

While AR shows more promise than VR, there has yet to be a “killer app” that everyone must have, the way smartphones have become essential for navigation and everyday snapshots.

Rather, people will discover AR over time, perhaps a few years. Someone renovating or moving might discover the furniture apps. New parents might discover educational apps. Those people might then go on to discover more AR apps to try out. But just hearing that AR is available might not be enough for someone to check it out.

Consider mobile payments. Most phones now have the capability, but people still tend to pull out plastic when shopping. There’s no doubt more people are using mobile payments and more retailers are accepting them, but it’s far from commonplace.

Expect augmented reality to also take time to take off.

Climate to Push Forest-eating Beetles to Northern US, Canada, Scientists Predict

Forests in the northeastern United States and southern Canada could be ravaged by tree-killing beetles in coming decades as a warming climate expands the pest’s habitat, a study has found.

Over the next 60 years, southern pine beetles could infest forests in new areas of the United States and Canada, disrupting industries and ecosystems alike, it said.

Warmer winter nights allow spread

The red-brown insects, the size of a grain of rice, known to feast on pine-tree bark, has typically only thrived in the hotter climate of Central America and the southeastern United States.

But in recent years warmer than usual winter nights have allowed it to survive the cold months and spread as far north as the U.S. state of New York. The coldest winter night has warmed by 6 to 7 degrees Fahrenheit (3 to 4 degrees Celsius) over the past 50 years in various parts of the United States, the study’s authors said.

Using computer-based climate models, they predicted the beetles should gradually march north along the Atlantic coast, infesting forests including in the U.S. states of Maine and Ohio all the way to Canada’s Nova Scotia.

Pest moves fast

By 2080, the pest should proliferate to red — and jack-pine forests in a 270,000 square miles (700,000 square km) area of the United States and Canada — roughly the size of Afghanistan, the researchers wrote in Nature Climate Change.

That would not only upend ecosystems, but also disrupt several key industries “in already struggling rural areas,” said lead author Corey Lesk, a researcher at Columbia University in New York.

“Residents of these regions could see a direct hit to their pocketbooks,” he told the Thomson Reuters Foundation on Tuesday in a phone interview.

Infestations costly to timber industry

Where the southern pine beetle has struck in the past, timber industries have been hard hit.

Infestations of pine beetles have cost an estimated $100 million a year in timber losses from 1990 to 2004 in the southeastern United States, according to the U.S. Forest Service.

Thousands of adult beetles can kill a tree in two to four months as the insects carve S-shaped tunnels under the bark, depriving their host of needed nutrients.

The tourism industry would also likely suffer, said Lesk, with the potential destruction of iconic forests including the Pine Barrens of New Jersey and Long Island.

Europe faces same problem

In Europe, previous research has shown that bark beetles have similarly been chewing through pine and spruce trees in forests from the Swiss Alps to Belarus alongside temperature increases.

Land managers have found the best way to fight off bark beetles has been thinning high-density forests and cutting out infested trees, though with limited success, the researchers said.

“The key question is whether those strategies would be able to keep up with rapid advance of the pest into regions with little or no experience managing it,” Lesk said.

 

US Spacecraft Readies for Fiery Plunge into Saturn After 13-year Mission

The U.S. space agency’s Cassini spacecraft will end its 13-year mission to Saturn in mid-September by transmitting data until the final moment before it plunges into the ringed planet’s atmosphere, officials said Tuesday.

Cassini, the first spacecraft to orbit Saturn, will make the last of 22 farewell dives between the planet’s rings and surface on Sept. 15. The spacecraft will then burn up as it heads straight into the gas giant’s crushing atmosphere.

Cassini’s final dive will end a mission that provided groundbreaking discoveries that included seasonal changes on Saturn, the moon Titan’s resemblance to a primordial Earth, and a global ocean on the moon Enceladus with ice plumes spouting from its surface.

“The mission has been insanely, wildly, beautifully successful, and it’s coming to an end in about two weeks,” Curt Niebur, Cassini program scientist, said on a telephone conference call with reporters from NASA’s Jet Propulsion Laboratory in California.

Cassini’s final photo as it heads into Saturn’s atmosphere will likely be of propellers, or gaps in the rings caused by moonlets, said project scientist Linda Spilker.

The spacecraft will provide near real-time data on the atmosphere until it loses contact with Earth at 4:54 a.m. PDT (1154 GMT) on Sept. 15, the National Aeronautics and Space Administration said.

Spilker said Cassini’s latest data on the rings had shown they had a lighter mass than forecast. That suggests they are younger than expected, at about 120 million years, and thus were created after the birth of the solar system, she said.

During its final orbits between the atmosphere and the rings, Cassini also studied Saturn’s atmosphere and took measurements to determine the size of the planet’s rocky core.

Cassini has been probing Saturn, the sixth planet from the sun, and its entourage of 62 known moons since July 2004. It has provided enough data for almost 4,000 scientific papers.

Since the craft is running low on fuel, NASA is crashing it into Saturn to avoid any chance Cassini could someday collide with Titan, Enceladus or any other moon that has the potential to support indigenous microbial life.

By destroying the spacecraft, NASA will ensure that any hitchhiking Earth microbes still alive on Cassini will not contaminate the moons for future study.

World Bank: Tackle Middle East Water Scarcity to Save Money, Boost Stability

The Middle East and North Africa region loses about $21 billion each year because of an inadequate supply of water and sanitation, the World Bank said Tuesday, warning that urgent action is needed to prevent ripple effects on stability and growth.

Poor management of water resources and sanitation in the world’s most water-scarce region costs about 1 percent of its annual gross domestic product, with conflict-hit states losing as much as 2 to 4 percent each year, the bank said in a report issued at the World Water Week conference in Stockholm, Sweden.

Deaths due to unsafe water and sanitation in some parts of the region, particularly countries affected by conflict, are higher than the global average, it added.

“As the current conflict and migration crisis unfolding in the Middle East and North Africa shows, failure to address water challenges can have severe impacts on people’s well-being and political stability,” the report said.

Peril in Yemen

In Yemen, which is reeling from more than two years of conflict, water supply networks serving its largest cities are at risk of collapse due to war-inflicted damage and disrepair, and about 15 million people have been cut off from regular access to water and sanitation, the U.N. children’s agency (UNICEF) said in a separate statement Tuesday.

In Syria, where the conflict is well into its seventh year, water has frequently been used as “a weapon of war,” with pumps deliberately destroyed and water sources contaminated, and about 15 million people are in need of safe water, including an estimated 6.4 million children, UNICEF said.

Overall, 183 million people lack access to basic drinking water in countries affected by conflict, violence and instability around the world, it added.

Better management

With the urban population in the Middle East and North Africa expected to double by 2050 to nearly 400 million, a combination of policy, technology and water management tools should be used to improve the water situation, the World Bank report said.

“Water productivity — in other words, how much return you get for every drop of water used — in the Middle East in general is the lowest on average in the world,” said Anders Jägerskog, a specialist in water resources management at the World Bank and one of the report’s authors.

Middle Eastern and North African countries are using far more water than can be replenished, said the report.

To reverse the trend, technology and innovation are “essential but not enough,” Jägerskog told the Thomson Reuters Foundation. Water governance — in particular, water tariffs and subsidies — must also be addressed, he said.

The region has the world’s lowest water tariffs and spends the highest proportion of GDP on public water subsidies. Such policies lead to excessive use of already scarce water supplies and are not sustainable, said Jägerskog.

Untreated wastewater

Another challenge is that more than half of the wastewater collected in the region is fed back into the environment untreated.

“Along with better water management, there is room for increasing the supply through nonconventional methods such as desalination and recycling,” Guangzhe Chen, senior director of the World Bank’s global water practice, said in a statement.

Improved water management could bring considerable financial returns, the report noted.

Governments could gain $10 billion annually by improving the storage and delivery of irrigation water to users, while increasing agricultural production by up to 8 percent, the report said.

Egypt, Syria and Iran — which have the largest proportion of irrigated land in the region — are the countries that could benefit most.

Mexico Dusts Off ‘Plan B’ as Trump Revs Up Threats to Kill NAFTA

Mexico sees a serious risk the United States will withdraw from NAFTA and is preparing a plan for that eventuality, Economy Minister Ildefonso Guajardo said Tuesday, calling talks to renegotiate the deal a “roller coaster.”

U.S. President Donald Trump has threatened three times in the past week to abandon the North American Free Trade Agreement, revisiting his view that the United States would probably have to start the process of exiting the accord to reach a fair deal for his country.

Trump has vowed to get a better deal for American workers, and the lively rhetoric on both sides precedes a second round of talks starting on Friday in Mexico City to renegotiate the 1994 accord binding the United States, Mexico and Canada.

“This is not going to be easy,” Guajardo said at a meeting with senators in Mexico City. “The start of the talks is like a roller coaster.”

The need for a backup plan in case Trump shreds the deal underpinning a trillion dollars in annual trade in North America has been a long-standing position of Guajardo, who travels to Washington on Tuesday with foreign minister Luis Videgaray to meet senior White House and trade officials.

“We are also analyzing a scenario with no NAFTA,” Guajardo said.

In an interview published earlier on Tuesday in Mexican business daily El Economista, Guajardo said “there is a risk, and it’s high” that the Trump administration abandons NAFTA.

Responding to Guajardo’s comments, Canadian Prime Minister Justin Trudeau said his government would continue to work “seriously” to improve NAFTA.

What is ‘Plan B’?

Earlier this month, Guajardo told Reuters a “Plan B” meant being prepared to replace items such as the billions of dollars in grain Mexico imports from the United States annually.

To that end, and to seek openings in more markets, Mexico is hosting trade talks with Brazil this week. Trade officials are also discussing a possible replacement for the Trans-Pacific Partnership trade pact that Trump ditched after taking office.

Overlapping with the NAFTA talks, Mexico will participate in separate trade meetings with Australia and New Zealand in Peru, and President Enrique Pena Nieto travels to China this weekend.

Still, attempts to diversify trade will not be easy. Some 80 percent of all Mexican exports go to the United States, and economies such as Brazil and China often compete with Mexico.

Guajardo also suggested World Trade Organization tariffs that would kick in if NAFTA crumbled would be more favorable for Mexico, a view held by many Mexican experts who think trade with the United States would survive the demise of the 1994 deal.

“I don’t think it’s going to make that much of a difference in terms of the trading relationship,” said Andres Rozental, a former Mexican deputy foreign minister. “If we have to go to WTO tariffs, for us it’s fairly straightforward.”

Guajardo’s and Videgaray’s trip to Washington was announced after Trump not only threatened to pull out of the trade deal, but again said that Mexico would end up paying for the wall he wants to build between the two countries.

Mexico has refused point blank to pay for a wall. In January, after similar comments led Mexico to scrap a summit with Trump, the two sides agreed not to talk in public about it.

Brazil Looks to China to Finish Nuclear Power Plant

Brazil will seek China’s expertise and financing to complete its third nuclear power plant when President Michel Temer makes a state visit to Beijing on Friday, Brazilian government officials said Tuesday.

The Brazilian nuclear energy company Eletronuclear will sign a cooperation agreement with China National Nuclear Corporation (CNNC), signaling their intent to establish a partnership to finish the Angra 3 plant, the officials said.

Construction of the 1,405-megawatt reactor on the coast south of Rio de Janeiro has dragged on for three decades and its completion is now scheduled for 2023, but Brazil does not have the estimated 16 billion reais ($5 billion) needed to finish the job.

Russia is also interested in completing Angra 3 and Eletronuclear, a subsidiary of state-run electric utility Eletrobras, has held talks with the Russian nuclear monopoly Rosatom.

The Chinese corporation is expected to have the advantage in terms of abundant financial resources.

The head of Eletronuclear, Bruno Barretto, signed an initial memorandum with CNNC on the Angra 3 completion in Beijing in December when he visited Chinese banks that are potential financiers, Eletronuclear said in a statement.

Temer’s government has announced plans to privatize Eletrobras, Latin America’s largest utility. But Eletronuclear will be split off and remain in state hands under Brazil’s Constitution, which establishes that nuclear facilities must be government controlled.

Temer said on Tuesday he expects China to be a major player in Brazil’s plans to modernize its ports, airports and other infrastructure projects that will be offered to investors in private concessions.

He also hopes China will finance energy projects.

“China could be one of the big investors in our plans for concessions,” he said in a video message released after he set off for Beijing, where he will meet Chinese President Xi Jinping ahead of the BRICS summit in Xiamen.

Syrian Schools Grow Edible Playgrounds to Boost Diets of Hungry Children

School playgrounds across Syria are being transformed into vegetable gardens where children whose diets have been devastated by six years of war can learn to grow — and then eat — aubergines, lettuces, peppers, cabbages and cucumbers.

Traditional Syrian cuisine is typical of the region, and rich in vegetables. Its mainstays include hummus, minced lamb cooked with pine nuts and spices, varied salads, stews made with green beans, okra or courgettes and tomatoes, stuffed cabbage leaves and artichoke hearts.

But the six-year war has changed that for much of the population, and many now live mainly on bread or food aid.

According to U.N. figures, unemployment now stands at more than 50 percent, and nearly 70 percent of the population is living in extreme poverty, in what was once a relatively wealthy country.

“The ongoing crisis in Syria is having a devastating effect on the health and nutrition of an entire generation of children,” Adam Yao, the U.N. Food and Agriculture Organization’s (FAO) acting representative in Syria, said on Tuesday, ahead of the start of the school year.

FAO is helping some 17 primary schools in both government and opposition-controlled areas to plant up to 500 meter-square fruit and vegetable plots in war-torn areas including Aleppo, Hama, Homs, Idlib and the outskirts of Damascus.

Young children are often the most vulnerable to malnutrition in a crisis, which can have serious and long-lasting effects on their growth and future development.

“Good nutrition is a child’s first defense against common diseases and important for children to be able to lead an active and healthy life,” Yao added.

The primary schools, which began planting in May, have produced 12 tons of fruit and vegetables. Another 35 schools are expected to start transforming their playgrounds soon in Aleppo and in rural areas around Damascus.

Rising prices, falling production

The price of food has risen since the start of the war — agriculture production has plummeted, and the country now relies on food imports to make up the shortfall. Transporting food around the country has also become difficult and costly.

About 13.5 million people in Syria are in need of humanitarian assistance. Of those, 7 million are unable to meet their basic food needs.

Some 5 million people receive international food aid, but not everyone in need can be reached, and the World Food Program says it has had to cut the amount of calories in its family food baskets because of funding shortages.

“The donors are generous, but we don’t know how long they can continue to be generous and rely on taxpayers’ money,” the FAO’s Yao told Reuters.

Vulnerable families are receiving help from FAO to grow food at home, so they can become less reliant on food aid.

“Food aid is very important, but … we should combine both, in a way that people grow their own food and move away from food aid gradually,” he said.

In a country where more than half the population has been forced to flee their homes, many moving several times, investing in agriculture helps people to stay put for as long as it is safe, Yao added.

“Agriculture has become a hope for [many] because they can grow their own food and survive — even in the besieged areas.”

Brazil Revises Decree Allowing Amazon Mining After Criticism

Brazil’s government has revised a decree that stripped protections from a reserve in the Amazon after environmental groups criticized the original order.

The new decree announced late Monday still lifts the reserve designation from a gold- and copper-rich area larger than the Netherlands in two northern Brazilian states.

 

But President Michel Temer’s administration clarifies that mining will not be allowed in conservation or indigenous areas within the former reserve.

 

The government says the new decree will allow it to crack down on the illegal mining that was taking place in the reserve, while opening up legal mining.

 

The Brazilian branch of the World Wide Fund for Nature said in a statement that the new decree clarifies the need for protection, but the risk of environmental damage remains.

US Attorney General: Opioid Crisis Is America’s ‘Top Lethal Issue’

U.S. Attorney General Jeff Sessions called the opioid crisis America’s “top lethal issue” Tuesday, saying that a “comprehensive antidote” was needed to address the crisis.

Speaking from the National Alliance for Drug Endangered Children national conference in Green Bay, Wisconsin, Sessions thanked the audience for their work in making the crisis’ effects on children known.

“Our country, despite the record deaths, I don’t think has fully recognized the damage this addiction nightmare is doing to us,” he said. “And as you understand this epidemic is taking a heavy toll on the most innocent and vulnerable — our children. And yet, in the national conversation about drug abuse, these children are too often forgotten.”

Sessions said that the solution has “three-pillars” — prevention, enforcement, and treatment. Sessions added that the prevention step in particular had been discussed at a meeting with top officials, including Secretary of State Rex Tillerson, and White House Chief of Staff John Kelly the day before.

Earlier this month, President Donald Trump vowed that the U.S. would “win” the battle against the heroin and opioid plague, but he stopped short of declaring a national emergency as his handpicked commission had recommended.

US Gearing Up for Digital Arms Race

In the straight-laced world of the U.S. military, the big room with glossy white paint stands out.

Beyond the desks lined with computer screens, the overhead projectors or the digital clock displaying the time in various world cities, the walls demand your attention.  

 

They are covered from floor to ceiling with questions, equations, sketches and ideas — scribbled frantically or in moments of inspiration — all representing the best thinking of some of the U.S. military’s best analysts.

 

“There are precious few places in this building where you can write on a wall,” said Albert Bolden, not surprisingly given that this is, after all, part of a military base.

But according to Bolden, the director of innovation at the U.S. Defense Intelligence Agency, that’s part of the point for the so-called Innovation Hub, or iHUB.

 

“People from across the agency can come into this space and figure out how to solve our problems,” he said.

 

‘Relevant in this digital age’

 

While all this may sound like a feel-good tale of military structure melding with Silicon Valley ingenuity to make life easier by using technology, it is actually about much more.

 

“If we don’t embrace it, our adversaries will,” said outgoing DIA Director, Lt. Gen. Vincent Stewart. “The fight for remaining relevant in this digital age is what keeps me awake.”

 

And Stewart was clear. It is, in many ways, an arms race.

 

“Our adversaries have been modernizing,” he warned, speaking to a small group of reporters in August, as the agency welcomed private companies and academics to the iHub for a series of so-called Industry Days.

 

And it is these encounters between the DIA’s own top thinkers and some of the best outside of government that form a second, crucial component of the iHub strategy. It is a chance to see how off-the-shelf technologies might be able to help solve problems the agency’s analysts have identified.

 

One company making a pitch to be part of this overall effort is an Austin, Texas-based artificial intelligence start-up called SparkCognition.

 

SparkCognition already has attracted interest from the U.S. Air Force. And companies like Verizon and Boeing are now investing more than $30 million in the company’s neural networks, designed to mimic the functionality of a human brain in order to predict likely outcomes.

 

“What we’ve done is automate that research that a data scientist would do,” said SparkCognition’s Sam Septembre following a question-and-answer session at the DIA’s iHub.

 

Instead of taking weeks or days, however, Septembre said SparkCognition’s systems can deliver results in hours or even minutes.

 

“We’re not just a black box,” added the company’s director of business operations, Timothy Stefanick. “We have why the [computer] model thought that.”

 

SparkCognition says its platforms already have succeeded in predicting Brexit, Britain’s decision to leave the European Union. And the company says it nearly correctly predicted President Donald Trump’s victory in the 2016 U.S. presidential election by looking at sales of campaign merchandise, like Trump’s “Make America Great Again” baseball caps.

 

“The human factor got involved and skewed it,” said Stefanick, explaining that in the run-up to the election, the company’s analysts didn’t trust the initial prediction of a Trump victory because it differed so much from the polls. He said they then decided to have the computer models take into account additional factors, causing them to predict a Trump loss.

 

AI for video

 

Another company vying for a DIA contract is Percipient.ai, which focuses on applying artificial intelligence to video.

 

“This is a kind of capability that helps you get into productive analytics and helps you protect forces,” said company co-founder, ret. Brig. Gen. Balan Ayyar, a former U.S. Air Force intelligence officer who commanded a task force in Afghanistan.

“You can check any person in any video,” he said.

 

Ayyar and fellow Percipient.ai co-founder Raj Shah, say their platform can save analysts considerable time, for example scouring hundreds of hours of video from the scene of a terror attack to quickly identify if any suspected terrorists were nearby.

 

Even mobile phones could be used to track potential adversaries, programmed to vibrate, for instance, if a person of interest turns up in a “selfie.”

 

“With this kind of system, the [terror] watch list could be much, much bigger,” said Shah, who previously headed up Google Maps.

 

Already, Ayyar and Shah say Percipient.ai’s systems can identify suspicious activity, or tradecraft, like the use of specific getaway vehicles.

Handwriting on the wall

 

For DIA, the early results have been promising.

 

“We’ve seen examples when machines are able to provide insights to the analysts that they haven’t had,” said Randy Soper, a senior DIA analyst for analytics modernization.

 

To speed up the process, DIA even awards seed money — up to about $250,000 — to projects that have shown the most promise.

 

Two have already been approved and another four projects are set to receive funding once the once the money becomes available.

 

More projects could soon be added to the list. DIA’s Innovation Hub is still considering the latest pitches from industry and academia, like those from SparkCognition and Percipient.ai.

 

The agency says that overall, the response has been “overwhelming.”

 

But the success in reaching out to industry and academia also has brought some changes to the program.

 

Last week [August 22], the DIA opened up a new Innovation Hub.

 

At first glance, it looks sleek and modern, a row of screens and a digital world clock etched smoothly into wood-paneled walls, while a large conference table dominates the center of the room.

 

To be sure, it seems like quite a departure from the old iHub, which almost had the feel of a useful but makeshift classroom.

 

Some things, though, have not changed. The wood-paneling only extends so far. Much of the rest of the room is covered in that white, glossy paint.

 

“You can still write on the walls,” said one official.

 

Wealthy Cocaine Users Funding Slavery, Says Former UK Drug Chief

Middle-class cocaine users are turning a blind eye to the link between their drug habit and sex trafficking, slavery and murder, said the former head of UK drug strategy.

“These are middle-aged, middle-class people at dinner parties,” Tony Saggers, former head of drugs threat at the National Crime Agency, told The Times on Tuesday, in his first interview since leaving the post.

“They will find sweatshops abhorrent, slave labor a brutal, terrible thing to be happening in their neighborhood, and the news that a 16-year-old has been knifed to death in London will shock them,” he added.

Britain has one of the highest rates of cocaine use in Europe, according to the European Commission and the Organization for Economic Cooperation and Development (OECD) with 4.2 percent of young adults having taken the drug in 2015.

Saggers said this was funding the exploitation of women in the sex industry, as well as slavery and gun violence.

“The consequences of buying cocaine are more abhorrent than most of what the people using it find abhorrent,” he said.

In Britain, there are an estimated 13,000 victims of forced labor, sexual exploitation and domestic servitude, most of them from Albania, Nigeria, Poland and Vietnam.

Saggers said there was a lack of action among employers in tackling the prevalence and acceptance of cocaine use in some industries, particularly among banks and other companies in the City of London, Britain’s financial center.

Companies should address the problem through schemes that educate their staff about the impact of cocaine abuse on their health and wider society, he added.

Tamara Barnett, projects leader at the Human Trafficking Foundation, said “we need to do all we can to emphasize the role the public can play in eradicating human trafficking.”

“Highlighting the exploitation and abuse behind certain drug production could make some people think twice before they purchase drugs, or at least twice before boasting about doing something that has for too long been seen just as a fashionable lifestyle choice,” she told the Thomson Reuters Foundation.

In 2015 a report by the National Police Chiefs’ Council found that commercial cultivation of cannabis was used to fund human trafficking.

Pizza Delivery Without Drivers: Domino’s, Ford Team Up for Test

No ring of the doorbell, just a text. No tip for the driver? No problem in this test, where Domino’s and Ford are teaming up to see if customers will warm to the idea of pizza delivered by driverless cars.

 

Starting Wednesday, some pizzas in Domino’s hometown of Ann Arbor will arrive in a Ford Fusion outfitted with radars and a camera that is used for autonomous testing. A Ford engineer will be at the wheel, but the front windows have been blacked out so customers won’t interact with the driver.

 

Instead, people will have to come out of their homes and type a four-digit code into a keypad mounted on the car. That will open the rear window and let customers retrieve their order from a heated compartment. The compartment can carry up to four pizzas and five sides, Domino’s Pizza Inc. says.

 

The experiment will help Domino’s understand how customers will interact with a self-driving car, says company President Russell Weiner. Will they want the car in their driveway or by the curb? Will they understand how to use the keypad? Will they come outside if it’s raining or snowing? Will they put their pizza boxes on top of the car and threaten to mess up its expensive cameras?

 

“The majority of our questions are about the last 50 feet of the delivery experience,” Weiner told reporters last week.

 

Domino’s, which delivers 1 billion pizzas worldwide each year, needs to stay ahead of emerging trends, Weiner says. The test will last six weeks, and the companies say they’ll decide afterward what to do next. Domino’s is also testing pizza delivery with drones.

 

Weiner said the company has 100,000 drivers in the U.S. In a driverless world, he said, he could see those employees taking on different roles within the company.

 

Ford Motor Co., which wants to develop a fully driverless vehicle by 2021, said it needs to understand the kinds of things companies would use that vehicle for. The experiment is a first for Ford. But other companies have seen the potential for food deliveries. Otto, a startup backed by Uber, delivered 50,000 cans of Budweiser beer from a self-driving truck in Colorado last fall.

 

“We’re developing a self-driving car not just for the sake of technology,” said Sherif Marakby, Ford’s vice president of autonomous and electric vehicles. “There are so many practical things that we need to learn.”

 

Only one car will be deployed in Ann Arbor, and it has a special black-and-white paint job to identify it as a research vehicle.

 

Customers in the test area will be chosen randomly when they order a pizza, and will get a phone call to confirm they want to participate. If they agree, they’ll get a text message letting them know when the vehicle is pulling up and how to retrieve their food.