New Way of Defining Alzheimer’s Aims to Find Disease Sooner

Government and other scientists are proposing a new way to define Alzheimer’s disease basing it on biological signs, such as brain changes, rather than memory loss and other symptoms of dementia that are used today.

The move is aimed at improving research, by using more objective criteria like brain scans to pick patients for studies and enroll them sooner in the course of their illness, when treatments may have more chance to help.

But it’s too soon to use these scans and other tests in routine care, because they haven’t been validated for that yet, experts stress. For now, doctors will still rely on the tools they’ve long used to evaluate thinking skills to diagnose most cases.

Regardless of what tests are used to make the diagnosis, the new definition will have a startling effect: Many more people will be considered to have Alzheimer’s, because the biological signs can show up 15 to 20 years before symptoms do.

“The numbers will increase dramatically,” said Dr. Clifford R. Jack Jr., a Mayo Clinic brain imaging specialist. “There are a lot more cognitively normal people who have the pathology in the brain who will now be counted as having Alzheimer’s disease.”

He led a panel of experts, working with the Alzheimer’s Association and the National Institute on Aging, that updated guidelines on the disease, published Tuesday in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 

About Alzheimer’s

About 50 million people worldwide have dementia, and Alzheimer’s is the most common form. In the U.S., about 5.7 million have Alzheimer’s under its current definition, which is based on memory problems and other symptoms. About one-third of people over 70 who show no thinking problems actually have brain signs that suggest Alzheimer’s, Jack said.

There is no cure – current medicines such as Aricept and Namenda just temporarily ease symptoms. Dozens of hoped-for treatments have failed, and doctors think one reason may be that the studies enrolled patients after too much brain damage had already occurred.

“By the time that you have the diagnosis of the disease, it’s very late,” said Dr. Eliezer Masliah, neuroscience chief at the Institute on Aging.

“What we’ve realized is that you have to go earlier and earlier and earlier,” just as doctors found with treating cancer, he said.

Another problem: as many as 30 percent of people enrolled in Alzheimer’s studies based on symptoms didn’t actually have the disease – they had other forms of dementia or even other medical conditions. That doesn’t give an accurate picture of whether a potential treatment might help, and the new definition aims to improve patient selection by using brain scans and other tests. 

Better tests

Many other diseases, such as diabetes, already are defined by measuring a biomarker, an objective indicator such as blood sugar. That wasn’t possible for Alzheimer’s disease until a few years ago, when brain scans and spinal fluid tests were developed to do this.

They measure certain forms of two proteins – amyloid and tau – that form plaques and tangles in the brain – and signs of nerve injury, degeneration and brain shrinkage.

The guidelines spell out use of these biomarkers over a spectrum of mental decline, starting with early brain changes, through mild impairment and Alzheimer’s dementia.

What to do?

People may be worried and want these tests for themselves or a family member now, but Jack advises: “Don’t bother. There’s no proven treatment yet.” 

You might find a doctor willing to order them, but spinal fluid tests are somewhat invasive, and brain scans can cost up to $6,000. Insurance usually does not pay because they’re considered experimental outside of research. A large study is underway now to see whether Medicare should cover them and when.

Anyone with symptoms or family history of dementia, or even healthy people concerned about the risk can consider enrolling in one of the many studies underway.

“We need more people in this pre-symptomatic stage” to see if treatments can help stave off decline, Masliah said. 

Apple Co-Founder Closing Facebook Account in Privacy Crisis

Apple co-founder Steve Wozniak is shutting down his Facebook account as the social media giant struggles to cope with the worst privacy crisis in its history.

In an email to USA Today, Wozniak said Facebook makes a lot of advertising money from personal details provided by users. He said the “profits are all based on the user’s info, but the users get none of the profits back.”

Wozniak said he’d rather pay for Facebook.

“Apple makes money off of good products, not off of you,” he said.

In an interview late Monday in Philadelphia with The Associated Press, Wozniak said he had been thinking for a while of deleting his account and made the move after several of his trusted friends deleted their Facebook accounts last week.

It’s “a big hypocrisy not respecting my privacy when (Facebook CEO Mark) Zuckerberg buys all the houses around his and all the lots around his in Hawaii for his own privacy,” Wozniak said. “He knows the value of it, but he’s not looking after mine.” 

A British data mining firm affiliated with Donald Trump’s Republican presidential campaign gathered personal information from 87 million Facebook users to try to influence elections. Facebook, based in Menlo Park, California, has announced technical changes intended to address privacy issues.

Zuckerberg has apologized, and Facebook’s No. 2 executive, Sheryl Sandberg, has said she’s sorry the company let so many people down.

Zuckerberg will testify on Capitol Hill on Tuesday and Wednesday about the company’s ongoing data privacy scandal and how it failed to guard against other abuses of its service.

Wozniak said he doesn’t believe in the current system that Facebook can fix its privacy issues, saying he doesn’t think Facebook is going to change its policies “for decades.”

Wozniak said Apple Inc., based in Cupertino, California, has systems and policies that in many cases allow people to choose whether to share certain data. He said he doesn’t foresee Apple not allowing the Facebook app to be bought or downloaded on its phones but said he does not make those decisions for the company. 

US Designers Use Repurposed Materials in High-End Interior Decor

Landfills around the world are getting overloaded with waste, much of it hazardous and slow to decompose. As it becomes increasingly difficult to find new places for discarded unwanted items, people around the world are looking for ways to re-use as much stuff as possible before throwing it away. Designers are embracing the trend and are increasingly using recycled materials in their new creations.

Facebook CEO Zuckerberg Faces Tough Questions on Capitol Hill

Facebook CEO Mark Zuckerberg faces tough questions on Capitol Hill this week following revelations that the Trump-affiliated political firm Cambridge Analytica accessed the data of as many as 87 million users of the social media site during the 2016 election. VOA’s Congressional correspondent Katherine Gypson looks at the questions lawmakers have been waiting to ask Zuckerberg and the next steps they may take.

China’s Xi Pledges to Cut Auto Tariffs, Press Ahead With Reforms

China’s President Xi Jinping did not mention U.S. President Donald Trump by name or speak directly about rising trade frictions with Washington during a closely watched speech at the Boao Forum — China’s version of Davos for Asia.

But the pledges Xi made to press forward with economic reforms had everything to do with the trade dispute and President Trump’s threats to levy heavy tariffs on Chinese goods.

In his speech, Xi mentioned the phrase “opening up” 42 times. One of the key messages of his speech was that China was open for business. It was also an effort, one analyst said, to highlight a contrast between Beijing’s approach and Washington.

“I want to clearly tell everyone, China’s door for opening will not close, but will only open wider,” Xi said. “Cold war mentality and zero sum game are more and more old-fashioned and outdated. Isolationism will only hit walls.”

Car imports

In his speech, Xi said China would launch a number of landmark measures this year, including cutting tariffs on car imports, one key trade barrier President Trump has mentioned repeatedly. China places a 25 percent tariff on automobile imports, while Chinese vehicles exported to the United States are taxed by two and half percent.

Xi re-stated a pledge to open up China’s financial sector — easing restrictions — and accelerate the opening up of the insurance industry.

He also said China would restructure its State Intellectual Property Office this year to step up law enforcement, raise fines for violations and strengthen legal protections.

Xi did not give a specific timeframe, but said the reforms would take place “sooner rather than later, faster rather than slower.”

Some analysts said the pledges were nothing new and unlikely to amount to the type of concessions that the Trump administration is expecting. Others, however, said there might be enough there to at least help the two move toward sitting down to talk.

“President Xi gave the outline and the many details and the concrete measures we are still waiting to see what policies will come up in the following days,” said Zhang Yifan, an associate professor at the Chinese University of Hong Kong. “But he mentioned balanced trade, that means that they will address the trade surplus issue, not just with the U.S., but with all other countries.”

The United States has proposed placing tariffs on about 1,300 Chinese imports, which amounts to about $50 billion in trade. Late last week, even as he disagreed with the characterization of the dispute as a trade war, President Trump upped the stakes by asking for $100 billion more in tariffs.

China has responded with a list of its own, some 106 products that target among other things agricultural production in areas where political support for Trump was strong in the 2016 elections.

Beijing has already put a 25 percent tariff in place on pork products, in response to Trump’s earlier tariffs on steel and aluminum. And if Beijing’s recently announced tariffs go forward, soybean imports from the United States could also face a 25 percent tariff.

The impact that could have on American farmers is already raising concerns. So much so that the White House announced Monday it is drafting up a plan to protect farmers and make sure they don’t bear the brunt of Chinese retaliation.

That is why it is hard to predict just how far Xi’s remarks may go in helping the two sides resolve their differences, said Oliver Rui, a professor of international finance and accounting at the China Europe International Business School.

“The issue is very complicated. It is not just the trade imbalances between the two countries, it is also related to political issues. The mid-term elections will definitely play a role here, the attitude of the EU will also play a role here,” Rui said.

Several days ago the White House chief economic adviser Larry Kudlow said that the Trump administration is building a “coalition of the willing” to jointly take on China over its trade practices. Kudlow has not yet said which countries might be a part of that grouping, but the European Union is one likely partner.

Concern about trade practices

The United States is not the only country concerned about China’s trade practices and increasingly analysts who have been arguing against tariffs have noted that working with other countries could have an even stronger impact.

That is something that President Xi appeared to be hinting at in his speech and that might be a point of concern for Beijing.

“We should pursue the path of dialogue, not conflict, building partnerships and not alliances as we forge new paths in relations between countries,” Xi said.

This story was written by VOA’s William Ide in Beijing. Joyce Huang contributed.

 

 

Busy Bees Turn Afghan Schoolgirl Into an Entrepreneur

In war-torn Afghanistan, honey is regarded as a traditional cure-all but for one schoolgirl, the sticky commodity has also created sweet opportunities to work and own a business in a country where few women do so.

Three years ago, Frozan, now 19 years old, obtained a small loan, bought two beehives and learned about apiculture from Hand in Hand International, a non-governmental organization that focuses on poverty.

The bees collected nectar from flowers growing near her home in the Marmul district in the northern Balkh province. Their first harvest produced about 16kg (35lb) of honey, which enabled Frozan to pay back her loan and still have money left over.

She now has 12 beehives and last year collected 110kg of honey, which earned her 100,000 Afghanis ($1,450) in a country where GDP per capita is only about $600.

“The village I live in is a traditional village and women are not allowed to work outside,” says Frozan, who goes by one name. “But when I started beekeeping I realized that it’s an easy task. I told the people about beekeeping and then they accepted it.”

Since the fall of the Taliban in 2001, the lives and status of women in society have improved significantly. But traditions, insecurity and recently a decline in international donors, have slowed progress.

A Human Rights Watch report, quoting government officials, says 85 percent of the 3.5 million children who don’t go to school are girls. Only 37 percent of adolescent girls are literate compared with 66 percent of adolescent boys.

Frozan is now in her final year of school and would like to study economics and grow her business, goals that may now be possible for her and her three siblings thanks to her income stream.

She says looking after tens of thousands of bees can easily be done between studies and household chores and her father, Ismail, who is a farmer like much of Marmul’s population, supports his daughter’s enterprise.

“It has been my dream to have a daughter who could find a job like this and make a future for herself,” he says.

Every few weeks, Ismail takes the fresh honey to Mazar-i-Sharif, the provincial capital, more than 50km away, where it’s sold to shops and consumed mainly by local customers.

While industry data is scant, local media citing government officials say Afghanistan’s honey production has risen in recent years, hitting 2,000 tons in 2015. Several varieties such as acacia, almond flower, and basil are now available.

However, infrastructure constraints mean most of this honey never leaves Afghanistan.

Iran Unifies Official and Open Market Exchange Rates as Rial Hit New Low

Iran unified the country’s official and open market exchange rates, state media said, after its currency, the rial, plunged to an all-time low on Monday on concerns over a return of crippling sanctions.

The U.S. dollar jumped in a day from 54,700 rials to 60,000 rials in the open market in Tehran on Monday. A dollar was worth 36,000 rials in mid-September.

After an emergency cabinet meeting, Iran’s First Vice President Eshaq Jahangiri was quoted by the state media as saying that from Tuesday the price of the dollar would be 42,000 rials in both markets, and for all business activities.

Iran has long been trying to unify its open market rate, used for most commercial transactions, with the official rate, which is a subsidized rate that is only available to government departments and some importers of priority goods.

Jahangiri said from Tuesday the government would not recognize any rate but the official rate, and “it would be illegal to trade dollars with an unofficial rate.”

U.S. sanctions lifted under Iran’s nuclear deal with world powers in 2015 will resume unless U.S. President Donald Trump waives them again on May 12. Trump has effectively set that as a deadline for European powers to fix what he called “the terrible flaws” of the deal.

President Hassan Rouhani warned on Monday that Trump will regret it if he pulls out of the nuclear deal.

Jaw Fossil From English Beach Belongs to Monstrous Marine Reptile

A jawbone fossil found on a rocky English beach belongs to one of the biggest marine animals on record, a type of seagoing reptile called an ichthyosaur that scientists estimated at up to 85 feet (26 meters) long – approaching the size of a blue whale.

Scientists said on Monday this ichthyosaur, which appears to be the largest marine reptile ever discovered, lived 205 million years ago at the end of the Triassic Period, dominating the oceans just as dinosaurs were becoming the undisputed masters on land. The bone, called a surangular, was part of its lower jaw.

The researchers estimated the animal’s length by comparing this surangular to the same bone in the largest ichthyosaur skeleton ever found, a species called Shonisaurus sikanniensis from British Columbia that was 69 feet (21 meters) long. The newly discovered bone was 25 percent larger.

“This bone belonged to a giant,” said University of Manchester paleontologist Dean Lomax.

“The entire carcass was probably very similar to a whale fall in which a dead whale drops to the bottom of the sea floor, where an entire ecosystem of animals feeds on the carcass for a very long time. After that, bones become separated, and we suspect that’s what happened to our isolated bone.”

Fossil collector Paul de la Salle, affiliated with the Etches Collection in Dorset, England, found the bone in 2016 at Lilstock on England’s Somerset coast along the Bristol Channel.

“The structure was in the form of growth rings, like that of a tree, and I’d seen something similar before in the jaws of late Jurassic ichthyosaurs,” he said.

Ichthyosaurs swam the world’s oceans from 250 million years ago to 90 million years ago, preying on squid and fish. The biggest were larger than other huge marine reptiles of the dinosaur age like pliosaurs and mosasaurs. Only today’s filter-feeding baleen whales are larger. The blue whale, up to about 98 feet (30 meters) long, is the biggest animal alive today and the biggest marine animal ever.

The researchers estimated the new ichthyosaur at 66 to 85 feet long (20 to 26 meters).

It appears to have belonged to an ichthyosaur group called shastasaurids. Because the remains are so incomplete, it is unclear whether it represents a new ichthyosaur genus or is a member of a previously identified genus, said paleontologist Judy Massare of the State University of New York College at Brockport.

The research was published in the journal PLOS ONE.

This story was written by Reuters.

Fossil Human Finger from Saudi Desert is 90,000 Years Old

A fossil finger bone dating back about 90,000 years that was unearthed in Saudi Arabia’s Nefud Desert is pointing to what scientists are calling a new understanding of how our species came out of Africa en route to colonizing the world.

Researchers said on Monday the middle bone of an adult’s middle finger found at site called Al Wusta is the oldest Homo sapiens fossil outside of Africa and the immediately adjacent eastern Mediterranean Levant region, as well as the first ancient human fossil from the Arabian peninsula.

While the Nefud Desert is now a veritable sea of sand, it was hospitable when this individual lived – a grasslands teeming with wildlife alongside a freshwater lake.

Our species first appeared in Africa roughly 300,000 years ago. Scientists previously thought Homo sapiens departed Africa in a single, rapid migration some 60,000 years ago, journeying along the coastlines and subsisting on marine resources, said anthropologist Michael Petraglia of the Max Planck Institute for the Science of Human History in Germany.

This fossil of an intermediate phalanx bone, 1.2 inches (3.2 cm) long, suggests our species exited Africa far earlier.

“This supports a model not of a single rapid dispersal out of Africa 60,000 years ago, but a much more complicated scenario of migration. And this find, together with other finds in the last few years, suggests … Homo sapiens is moving out of Africa multiple times during many windows of opportunity during the last 100,000 years or so,” Petraglia said.

The discovery also shows these people were moving across the interior of the land, not coastlines, Petraglia added.

Numerous animal fossils were discovered, including hippos, wild cattle, antelopes and ostriches, University of Oxford archeologist Huw Groucutt said. Bite marks on fossilized bones indicated carnivores lived there, too.

Stone tools that hunter-gatherers used also were found.

“The big question now is what became of the ancestors of the population to which the Al Wusta human belonged,” Groucutt said.

“We know that shortly after they lived, the rains failed and the area dried up. Did this population die out? Did it survive further south in Arabia, where even today there are mountainous areas with quite high rainfall and coastal regions which receive monsoonal rains?” Groucutt added. “Or did the drying environment mean that some of these people were ‘pushed’ further into Eurasia, as part of a worldwide colonization?”

The research was published in the journal Nature Ecology and Evolution.

This story was written by Reuters.

New Projects in Brazil’s Amazon? Not Without Congressional Approval, says Court

Brazil’s government has been told that development projects, including hydropower dams, in protected areas can no longer go ahead without the prior approval of lawmakers.

Last week’s ruling by the supreme court followed the use by the government in recent years of the controversial “provisional measure”, a legal instrument that allowed the president to approve projects by reducing the size of protected areas.

Campaigners said the decision should ensure the country’s forests and reserves, including the Amazon rainforest, were better protected.

“This decision puts an end to a spree of provisional measures in the name of environmental de-protection,” said Mauricio Guetta, a lawyer at Instituto Socioambiental (ISA), an advocacy group.

In recent years, the government has used the measure to open up protected areas for controversial projects, including building two of Brazil’s largest hydropower dams – the Jirau and Santo Antonio – in the Amazon.

The use of the measure to shrink protected areas with immediate effect had brought “irreversible consequences, irreversible damage to the environment,” Guetta told the Thomson Reuters Foundation by phone.

The eight-judge bench ruled unanimously that using the provisional measure to reduce the size of protected areas for any reason was unconstitutional.

 

It followed a lawsuit in which the court heard the measure had been used in 2012 to allow trees in six protected areas of the Amazon to be felled to make way for five hydropower dams.

“The (provisional measure), later converted into law, reduced the level of environmental protection by deactivating due legislative process,” supreme court justice Alexandre de Moraes said in a statement.

The court said the ruling would not affect the five hydropower plants in question because the provisional measure had already been enacted in law, and some are operating.

Guetta said the ruling meant any changes to protected areas must be first approved by law, and local communities should be properly consulted about projects planned on their land.

“The government has been trying to reduce by more than 1 million hectares the area under conservation in the southern part of Amazonas state. Now this initiative is officially vetoed because of the supreme court’s decision,” he said.

Environmentalists say increasing swaths of land, including the Amazon forest, are being felled for grazing and cropland, and for development projects.

Deforestation in the Amazon fell in the August 2016 to July 2017 monitoring period for the first time in three years, although the 6,624 square kilometers (2,557 square miles) cleared of forest remains well above the low recorded in 2012 and targets for slowing climate change.

Apple: All Its Facilities Now Powered by Clean Energy

Apple on Monday said it had achieved its goal of powering all of the company’s facilities with renewable energy, a milestone that includes all of its data centers, offices and retail stores in 43 countries.

The iPhone maker also said nine suppliers had recently committed to running their operations entirely on renewable energy sources like wind and solar, bringing to 23 the total number to make such a pledge.

Major U.S. corporations such as Apple, Wal-Mart and Alphabet have become some of the country’s biggest buyers of renewable forms of energy, driving substantial growth in the wind and solar industries.

Alphabet’s Google last year purchased enough renewable energy to cover all of its electricity consumption worldwide.

Costs for solar and wind are plunging thanks to technological advances and increased global production of panels and turbines, enabling companies seeking to green their images to buy clean power at competitive prices.

“We’re not spending any more than we would have,” Lisa Jackson, Apple’s vice president for environment, policy and social initiatives, said in an interview. “We’re seeing the benefits of an increasingly competitive clean energy market.”

Renewable energy projects that provide power to Apple facilities range from large wind farms in the United States to clusters of hundreds of rooftop solar systems in Japan and Singapore. The company has also urged utilities to procure renewable energy to help power Apple’s operations.

Encouraging suppliers to follow suit in embracing 100 percent renewable energy is the next step for Apple. The suppliers that pledge to use more clean energy know they will have “a leg up” against competitors for Apple’s business, Jackson said.

“We made it clear that, over time, this will become less of a wish list and more of a requirement,” she said.

Pakistan Launches Countrywide Polio Eradication Drive

Pakistan launched a nationwide polio vaccination drive this week to try to reach 38.7 million children and eradicate the paralyzing and potentially deadly virus in one of the last countries where it is endemic.

Nearly 260,000 volunteers and workers fanned out across Pakistan in an effort to vaccinate every child below the age of five in a week-long campaign, Pakistan’s national coordinator on polio, Mohammad Safdar, said.

“We’re really very close to eradicating the disease,” Safdar told Reuters, appealing to the people to cooperate with the door-to-door effort.

Pakistan is one of only three countries in the world, along with Afghanistan and Nigeria, that suffers from endemic polio, a childhood virus that can cause paralysis or death.

In 2018, Pakistan has had just one polio case, reported last month, Safdar said. The number of cases has steadily declined since 2014 when 306 were reported. Last year, there were only eight cases, he said.

Efforts to eradicate the disease have been undermined by opposition from the Taliban and other Islamist militants, who say immunization is a foreign ploy to sterilise Muslim children or a cover for Western spies.

In January, gunmen killed a mother-and-daughter vaccination team working in the southwestern province of Baluchistan, where the year’s only case so far was later reporter.

Three years earlier, 15 people were killed in a bombing by the Pakistani Taliban outside a polio vaccination center in Baluchistan.

Polio teams working on Monday were undeterred.

“Yes we feel threatened, but our work is like this,” said Bilquis Omar, who has served on a mobile vaccination team for the past six years in the southern port metropolis of Karachi.

“We are working for the children,” she said.

Aziz Memon, who heads the Rotary Club’s PolioPlus program that funds many of the immunization teams, said this year the drive was also making a renewed effort to reach migrants who come back and forth from Afghanistan.

“Mission number one is to get to zero cases and eradicate polio,” Memon said.

A country must have no cases for three consecutive years in order to be considered to have eradicated polio by the World Health Organization.

Pakistan has to contend with extra suspicion of immunization drives because of the 2011 U.S. special forces raid inside the country that killed al-Qaida leader Osama bin Laden, architect of the Sept. 11 attacks on the United States in 2001.

A Pakistani doctor was accused of using a fake vaccination campaign to collect DNA samples that the CIA was believed to have been using to verify bin Laden’s identity. The doctor remains jailed in Pakistan, convicted of waging war against state.

This story was written by Reuters.

Smartphones Could Help Measure Parkinson’s Disease Symptoms

An experimental smartphone application could monitor changes in Parkinson’s disease symptoms throughout the day, sending data to doctors to help them treat patients, U.S. researchers say.

“Like diabetes, Parkinson’s has variability and symptom fluctuations, which can also vary the treatment. We can’t measure these fluctuations at home, and you can only do so many measurements in the clinic,” said senior study author Suchi Saria of Johns Hopkins University in Baltimore.

The app developed by Saria and her colleagues asks patients to complete five tasks that assess speech, finger tapping, gait, balance and reaction time. From that, it generates a “mobile Parkinson’s Disease score,” which doctors can use to assess symptom severity and adjust medication, the team writes in JAMA Neurology.

Parkinson’s disease is a neurodegenerative disorder that affects dopamine-producing nerve cells in the brain. Symptoms include tremors, body stiffness, slow movement and difficulty walking.

“This new development is very exciting because this wasn’t feasible even a few years ago,” Saria said in a telephone interview. “Patients seem eager, willing and curious to do this with their phones.”

The researchers developed their app, HopkinsPD, for Android smartphones to assess performance on the five tasks as often as patients want to use the app. The mobile score is based on the types of assessments usually done in doctor’s offices.

To test the app and the scoring system, the researchers recruited 129 patients who completed more than 6,000 smartphone assessments. Scores ranged from 0 to 100, with higher numbers indicating more severe symptoms. Participants completed the tasks before and after their first daily dose of dopamine medication. They also completed standard assessments in the clinic.

Symptoms varied by an average of 14 points through the day, information that could help doctors understand the highs and lows for their Parkinson’s patients.

The team also found a strong correlation between the mobile app score and the in-office rating scales. On average, the mobile app score also decreased more than the official scales when dopamine medication was taken, which could highlight its sensitivity and accuracy in monitoring real-time symptoms, the authors note.

“The data from the phone aligns beautifully with what we found with classic instruments in the clinic,” Saria said. “It gives us a sense of patients’ motion and movement, like breadcrumbs along the way to understanding their symptoms.”

A limitation of the study is that only five tasks are used to measure behaviors and symptoms, the authors acknowledge.

Additional studies will evaluate whether changes in the app score represent a significant difference experienced by patients.

“We physicians may measure phenomena we think are highly relevant, but patients may disagree,” said Dr. Alberto Espay, director of the James J. and Joan A. Gardner Center for Parkinson’s Disease and Movement Disorders at University of Cincinnati in Ohio, who wasn’t involved in the study.

“Also, it will be important to determine if the machine-learning component will require less active entry of data by patients, rendering it easier to use long-term,” Espay said in an email. “Long-term adherence will be important to ascertain if this application . . . can capture data for patients in their home settings.”

Researchers want to know whether elderly patients and those in developing countries can use similar apps, said Ye Wang of the National University of Singapore, who wasn’t involved in the current study.

“These ubiquitous technologies can and should be used to help doctors with their diagnosis,” Wang told Reuters Health by email.

“They are diagnostic aids and are not supposed to replace doctors,” he said. “But perhaps they can be part of the screening process.” 

SOURCE: JAMA Neurology

This story was written by Reuters.

Trump Family Hotel Business Asked Panama President for Help

Lawyers representing U.S. President Donald Trump’s family hotel business appealed to Panama’s president for help days before an emergency arbitrator declined to reinstate the Trump management team to a luxury waterfront hotel.

The Britton & Iglesias firm, which has represented the Trump Organization in its fight to continue running the hotel, addressed a letter dated March 22 to President Juan Carlos Varela.

 

A copy of the letter was provided to The Associated Press by contacts who have worked as a liaison to the building’s owners in Panama.

 

The letter asks Varela to intervene, complaining that Panama’s courts denied the organization due process in violation of a bilateral treaty and warning there could be consequences for the country.

 

It “URGENTLY requests his influence in relation to a commercial dispute involving Trump Hotel aired before Panama’s judiciary.”

 

In February, Orestes Fintiklis, the hotel’s majority owner, tried to fire Trump’s hotel management and take control of the property for the owners’ association. Trump’s family company beefed up security, but on March 5, judicial officials sided with Fintiklis. Police officers ordered the Trump management team out of the building.

 

On March 27, an arbitrator in the U.S. ruled that Trump’s company should not have been evicted while arbitration was ongoing with the hotel owners, but said he would not reinstate the previous management.

 

On Monday, Panama’s foreign secretary Isabel de Saint Malo, said her office had also been copied on the letter.

 

“It is a letter that urges Panama’s executive branch to interfere in an issue clearly of the judicial branch,” de Saint Malo said. “I don’t believe the executive branch has a position to take while the issue is in the judicial process.”

 

A source in Varela’s office who was not authorized to comment publicly confirmed Monday receipt of the letter.

 

Alan Garten, general counsel of the Trump Organization, did not respond to questions via email as to whether Trump knew about the appeal to Panamanian authorities.

 

Calls to Britton & Iglesias, as well as to Varela’s communications staff, were not immediately answered.

 

The letter goes on to say that the eviction violates the Bilateral Investment Treaty. “We appreciate your influence in order to avoid that these damages are attributed not to the other party, but to the Panamanian government,” the letter said, suggesting that the government, not the new management team, could be blamed for wrongdoing.

 

The letter raises questions about the president’s family business matter-of-factly requesting another president’s help in a private business matter by invoking a treaty signed by the U.S. and Panama. It essentially asks Panama’s president to ignore that country’s separation of powers and intervene in its judicial process.

 

A headline on the front page of Panama’s La Prensa newspaper Monday said, “Trump Organization Pressures Varela,” and coverage described the letter as a warning that there could be consequences for Panama if the old management team was not reinstated.

 

The letter was copied to Panamanian Cabinet officials, as well as presidents of the Supreme Court and National Assembly, among others.

 

The 70-story property on Panama City’s waterfront has been renamed The Bahia Grand Panama.

 

The emergency arbitration decision late last month said the case should have remained in arbitration and never gone to Panamanian courts.

 

Both sides continue fighting over who violated the hotel management contract.

 

 

Rice Breeders Report ‘Eye-Popping’ Productivity Gains

The grain that feeds half the world may have taken a big leap forward.

Scientists report the biggest improvements in rice productivity in decades.

If the results hold up in further tests, it could greatly increase harvests of a critical staple crop at a time when global population growing rapidly.

Researchers found one version of a gene that increased the number of branches in the flowering part of the plant. Each plant produced more rice as a result.

They used conventional breeding to introduce this gene version into five rice varieties. These varieties produced from 28 to 85 percent more rice than the parent strains, according to a new study in the journal Nature Scientific Reports.

That’s an “eye-popping” yield increase, said University of Arkansas rice breeder Xueyan Sha, who was not involved with this research. Normally, he added, “if we can achieve 6 percent, we can probably consider it a great achievement.”

Cautious optimism

Rice yields have not improved much since the 1960s “Green Revolution.” That’s when breeders found a gene that made plants shorter and less likely to fall over and therefore able to hold more rice grains. Farmers called the new variety “miracle rice” for its dramatic yield gains.

Experts say big increases in food production will be needed to feed the additional two billion or so people expected on the planet by 2050.

The new research was a small-scale, controlled experiment, Sha noted, and it’s not clear how the results will hold up in farmers’ fields. But he said he’s “cautiously optimistic.”

Not all rice varieties the scientists tested saw the same hefty productivity increases. That’s another reason for caution, according to rice geneticist Shannon Pinson with the U.S. Department of Agriculture.

“There’s something exciting here,” she said. “I don’t think it’s as exciting as Green-Revolution caliber.”

Study authors say their new rice varieties should be available to farmers in two to four years.

87M Facebook Users Will Find Out Whether Their Data Was Compromised

Social media giant Facebook is starting to notify 87 million of its users whether their personal data was harvested without their knowledge by Cambridge Analytica, the Britain-based voter profiling company U.S. President Donald Trump’s campaign hired to target likely supporters in 2016.

Facebook believes most of the affected users, more than 70 million, are in the United States, but there are also more than a million each in the Philippines, Indonesia and Britain.

The company has apologized for the security breach, with Facebook founder and CEO Mark Zuckerberg acknowledging the company made a “huge mistake” by not more closely monitoring use of the data and not taking a broad enough view of the company’s responsibilities.

Facebook allowed a British researcher to create an app on Facebook on which about 200,000 users divulged personal information that academic Alexsandr Kogan subsequently shared with Cambridge Analytica.  The number of affected Facebook users multiplied exponentially, however, because of the data collected from all the friends, relatives and acquaintances the 200,000 had online Facebook contact with.

Cambridge Analytica says it only had data for 30 million Facebook users.

Zuckerberg is meeting privately with lawmakers in Washington about the controversy and then testifying publicly Tuesday and Wednesday before two congressional committees.

Facebook is sending a notice to all of its 2.2 billion users with a link to see what apps they use and instructions on how they can, if they wish, shut off third-party access to their apps.

 

Trump Decries ‘Stupid Trade’ with China

U.S. President Donald Trump on Monday touted the United States’ “very good relationship with China” and his “good” friendship with President Xi Jinping, but again accused China of taking advantage of the United States for far too long.

Surrounded by Cabinet officials before a White House meeting Monday, Trump said the trade deal between the U.S. and China includes “the most lopsided set of trade rules and regulations that anybody has ever seen.” Rather than blame Beijing, however, Trump criticized previous U.S. presidents, representatives, and negotiators for the current trade situation.

Trump threatened to impose tariffs on an additional $100 billion worth of Chinese goods last week after Beijing threatened to target $50 billion worth of U.S. products — including soybeans and small aircraft — for possible tariff increases. 

Experts have warned that if the tariffs go into effect, U.S. farmers, who rely heavily on exporting their agricultural products to China, will be among the first casualties.

“If we do a deal with China, if during the course of negotiation, they want to hit the farmers because they think that hits me, I wouldn’t say that’s nice, but our farmers are great patriots. They understand that they are doing this for the country and we’ll make it up to them. In the end, they are going to be much stronger than they are right now,” Trump said.

Earlier Monday, Trump decried “stupid trade” with China, contending that U.S. automakers are hurt by hefty tariffs on their exports while the U.S. imposes a much smaller tax on imported Chinese vehicles.

Sales of Chinese-made cars in the U.S. are minimal, but some U.S. automakers have started making certain models in China for export to the U.S. Sales of U.S. cars in China subject to the 25 percent import tax push the cost of the vehicles thousands of dollars higher for Chinese buyers than the same models sell for in the U.S.

Trump’s broadside against China came a day after he predicted the U.S. and China would resolve their escalating fight over tariffs; but, there was no immediate end to the standoff, with the Chinese Foreign Ministry saying that trade talks with the U.S. are impossible under current conditions.

“China will take down its Trade Barriers because it is the right thing to do,” Trump tweeted Sunday, without offering any direct information. “Taxes will become Reciprocal & a deal will be made on Intellectual Property. Great future for both countries!”

China and the U.S. have published lists of goods they intend to tax, with the U.S. hitting steel and aluminum imports from China, along with aerospace, tech and machinery goods. Other levies would target medical equipment, medicine and educational materials.

China said it would impose tariffs on more than 100 U.S. products, including soybeans, wheat, corn, beef, tobacco, vehicles, plastic products and an array of other items.

Trump’s chief economic adviser, Larry Kudlow, on Monday played down fears the world’s two largest economist are on the brink of a trade war.

“First, we have a very strong economy,” said Kudlow, who also emphasized “no tariffs have been enacted” and that both sides are engaged in conversations. “That is not a trade war,” he said.

Gary Hufbauer, a senior fellow at the Washington-based Peterson Institute for International Economics, told VOA that Trump and his top administration officials recognize that the tariffs from both sides would be “very damaging to both economies.”

“The short-term impact would be highly adverse,” he said. ”Both sides have a lot to gain by negotiations rather than actually implementing a tariff war.”

VOA’s Victor Beattie contributed to this report.

China: US Trade Talks Currently ‘Impossible’

China’s Foreign Ministry said Monday that trade talks with the United States are impossible under current conditions.

The comment from spokesman Geng Shuang during a briefing with reporters came a day after U.S. President Donald Trump predicted there would be a resolution of the U.S.-China standoff on tariffs on hundreds of billions of dollars of goods the world’s two biggest economies are threatening to impose on each other.

“China will take down its Trade Barriers because it is the right thing to do,” Trump said, without offering any direct information. “Taxes will become Reciprocal & a deal will be made on Intellectual Property. Great future for both countries!”

Regardless, Trump said that he and Chinese President Xi Jinping “will always be friends, no matter what happens with our dispute on trade.”

The threats Washington and Beijing have lobbed at each other in recent days have rattled world stock markets, with wide swings of hundreds of points in stock indexes.

U.S. stocks plunged more than 2 percent Friday after Trump threatened to impose tariffs on an additional $100 billion worth of Chinese goods beyond the $50 billion worth of products he had already said would be affected.

Beijing responded in kind, saying it would impose tariffs on U.S. goods “until the end at any cost.”

Both countries have published lists of goods they intend to tax, with the U.S. hitting steel and aluminum imports from China, along with aerospace, tech and machinery goods. Other levies would target medical equipment, medicine and educational materials.

China said it would impose tariffs on more than 100 U.S. products, including soybeans, wheat, corn, beef, tobacco, vehicles, plastic products and an array of other items.

U.S. Treasury Secretary Steven Mnuchin told CBS News that the threat of higher tariffs posed the risk of a trade war but that he does not expect one to materialize.

“Our expectation is that we don’t think there will be a trade war. Our objective is to continue to have discussions with China. I don’t expect there will be a trade war. It could be, but I don’t expect it at all,” he said.

Mnuchin said that Trump and Xi have a “very close relationship” and that the two countries would continue to discuss trade issues.

A key U.S. lawmaker, Republican Sen. Lindsey Graham of South Carolina, told ABC News, that U.S. businesses and consumers could inevitably be hurt if China imposes tariffs on U.S. products.

“There is no way for us to address China without absorbing some pain here,” Graham said. “To those who believe that China is cheating, what idea do you have better than Trump?”

Gary Hufbauer, a senior fellow at the Washington-based Peterson Institute for International Economics, told VOA that Trump and his top administration officials recognize that the tariffs from both sides would be “very damaging to both economies.”

“The short-term impact would be highly adverse,” he said. “Both sides have a lot to gain by negotiations rather than actually implementing a tariff war.”

Russia to Support Companies Hit by US Sanctions

Russia said Monday it will support companies hit by fresh U.S. sanctions as Russian stocks dropped and shares in aluminum producer Rusal plummeted.

 

Deputy Prime Minister Arkady Dvorkovich said in comments reported by state news agencies that Russia is prepared to back the companies if their positions worsen.

“We have a very attentive approach to our leading companies. They mean thousands of employees and very important jobs for our country,” he was quoted as saying by the TASS agency.

 

Shares in Rusal, which is controlled by billionaire businessman Oleg Deripaska, plunged just over 50 percent on the Hong Kong stock exchange Monday.

 

Rusal said the sanctions “may result in technical defaults in relation to certain credit obligations.”

 

“The company’s initial assessment is that it is highly likely that the impact may be materially adverse to the business and prospects of the group,” Rusal said in a statement.

Deripaska controls a business empire with assets in aluminum, energy and construction. He has figured in Russian election-meddling investigations in the U.S. due to his ties to former Donald Trump campaign chairman Paul Manafort, who once worked as his consultant. The 55-year-old Deripaska is worth $5.3 billion, according to Forbes magazine.

 

On the Moscow stock exchange, the flagship MOEX index traded down over 6.5 percent as of early Monday afternoon, having partially recovered from a steeper slump which took the index down almost 10 percent. Metals companies were among the main losers.

 

The euro traded above 73 rubles for the first time since September 2016, while the dollar neared the 60-ruble mark.

 

The U.S. Treasury Department on Friday announced sanctions against seven leading Russian businessmen, 17 officials and a dozen Russian companies.

 

Besides Deripaska, targets included Alexei Miller, the head of state natural gas giant Gazprom, and Andrey Kostin, the head of the state-controlled VTB Bank, which is Russia’s second-largest.

 

There was also a place on the list for Kirill Shamalov, who is reportedly Putin’s son-in-law, married to his daughter Katerina Tikhonova, although neither Putin nor the Kremlin have acknowledged that she is his daughter. In 2014, Shamalov acquired a large share of Russian petrochemical company Sibur, later selling most of his stake for an undisclosed sum.

ANALYSIS-Obesity Among Asia-Pacific Children is Growing Health Crisis

Obesity rates among children in Asia-Pacific are rising at a rapid rate, and more action is needed to encourage healthier lifestyles and ease pressure on fledgling healthcare systems, researchers said.

The number of overweight children under five rose 38 percent between 2000 and 2016 in the region, and the problem is growing, said Sridhar Dharmapuri, a food safety and nutrition officer at the U.N.’s Food and Agriculture Organization (FAO) in Bangkok.

“The rate of growth in obesity in Asia-Pacific is higher than in many other countries,” Dharmapuri told the Thomson Reuters Foundation.

“While the United States leads the way on obesity rates, the number of overweight children in Asia-Pacific is rising rapidly, and many countries in this region are now among the most health-threatened in the world.”

Adult obesity rates are highest in the United States, Mexico, New Zealand and Hungary, and lowest in Japan and South Korea, according to a report on member states by the Paris-based Organization for Economic Co-operation and Development.

But the rapid rise in obesity among young people in Asia-Pacific is worrying because overweight children are at higher risk of becoming obese as adults and then developing serious health problems like type 2 diabetes, high blood pressure and liver disease.

Malaysia, Indonesia, Singapore and Thailand are among the most overweight countries in Southeast Asia, while Samoa, Tonga and Nauru are the most overweight in the Pacific. Australia also has high rates of obesity.

Many of these nations are also struggling to tackle malnutrition among their citizens.

The cost to the Asia-Pacific region of citizens being overweight or obese is $166 billion a year, a recent report by the Asian Development Bank Institute (ADBI) said.

Rising wealth levels over the last 20 years have played a major role in the rise in obesity levels, researchers say.

“The region has undergone economic growth, so food has become available at a relatively cheaper price,” said Matthias Helble, an economist at the ADBI in Tokyo.

“For the last 20 years the economic growth has been almost uninterrupted,” said Helble, who has researched obesity levels in the region for three years.

The “obesity time bomb” will be discussed by the 46 member governments attending the FAO conference for Asia and the Pacific, which starts in Fiji from Monday.

Lifestyle choices

In addition to consuming more, as economies have grown, people in Asia-Pacific have moved away from farming into manufacturing, and then to service sector jobs – which are more sedentary, researchers said.

Cities in Asia-Pacific have also seen unprecedented growth over the last two decades; this year more than half the region’s population will for the first time be urban, the United Nations has estimated.

City-dwellers in Asia-Pacific can spend hours commuting – due to poor transport systems and infrastructure – and when they finally reach home they have little time to cook. Many opt to eat out.

This new lifestyle has caused a rise in the consumption of convenience and processed foods, which often contain excess fats and more salt and sugar, researchers said.

People in the region also struggle to maintain a balanced diet, said Dharmapuri, with meals often lacking vegetables.

“The diet is largely rice-based,” he said. “On anybody’s plate, rice takes up between 50-70 percent of the space.”

When people are overweight they often suffer from other health problems, economists said, and this is likely to put pressure on public healthcare systems that are only just being established in many Asia-Pacific nations.

Absenteeism from work is also higher among obese people, said Helble, adding that overweight people often die earlier than those who lead healthy lives, so have a shorter productive life.

“The term ‘obesogenic environment’ has been used to describe an environment that promotes obesity among individuals and populations,” Elizabeth Ingram of the Australian Institute of Health and Welfare — a government statistics agency — said by email.

“It includes physical, economic, political, and sociocultural factors.”

Joint effort

Fixing the problem will likely take years, and researchers said a joint effort by business and governments was needed.

Better labeling on foods to promote healthier options, education about healthier diets and lifestyles, and even healthier school meals would improve the situation, analysts said.

“Being obese can also be seen as a sign of prosperity, because you have enough food to show your wealth through the fact that you have a lot to eat,” said Helble.

Sugar taxes, which have been introduced or are being discussed in the Philippines, Singapore and Indonesia, are also one way to change people’s mindset, he added.

Building more sports facilities at schools and ensuring urban planners include recreational areas for cities and make them more walkable and less polluted, is also crucial.

 

Governments must work with retailers, like in Singapore, to create a coordinated approach on packaging and promote a balanced diet, researchers said.

Working with retailers to ban unhealthy and sweet foods from checkout areas, and pushing street vendors to switch from fried foods to healthier, more traditional options, are also key.

And countries should adopt a “farm to fork” approach, which encourages farmers to diversify what they grow and be less reliant on growing just rice, said Dharmapuri.

“In some Pacific island countries, it’s actually easier to buy soft drinks and processed foods than buy fruits and vegetables,” said Dharmapuri. “It’s almost a delicacy to have a vegetable in a restaurant.”

Five Questions for Mark Zuckerberg as He Heads to Congress

Congress has plenty of questions for Facebook CEO Mark Zuckerberg, who will testify on Capitol Hill Tuesday and Wednesday about the company’s ongoing data-privacy scandal and how it failed to guard against other abuses of its service.

 

Facebook is struggling to cope with the worst privacy crisis in its history – allegations that a Trump-affiliated data mining firm may have used ill-gotten user data to try to influence elections. Zuckerberg and his company are in full damage-control mode, and have announced a number of piecemeal technical changes intended to address privacy issues.

 

But there’s plenty the Facebook CEO hasn’t yet explained. Here are five questions that could shed more light on Facebook’s privacy practices and the degree to which it is really sorry about playing fast and loose with user data – or just because its practices have drawn the spotlight.

 

QUESTION 1: You’ve said you should have acted years ago to protect user privacy and guard against other abuses. Was that solely a failure of your leadership, or did Facebook’s business model or other factors create an obstacle to change? How can you ensure that Facebook doesn’t make similar errors in the future?

 

CONTEXT: Zuckerberg controls 59.7 percent of the voting stock in Facebook. He is both chairman of the board and CEO. He can’t be fired, unless he fires himself. “At the end of the day, this is my responsibility,” he told reporters on a conference call last week. He also admitted to making a “huge mistake” in not taking a broad enough view of Facebook’s responsibility in the world.

 

Zuckerberg, however, has been apologizing for not doing better on privacy for 11 years . In the current crisis, neither he nor chief operating officer Sheryl Sandberg have clarified exactly how Facebook developed such a huge blind spot, much less how it can prevent history from repeating itself.

 

POSSIBLE FOLLOW-UP: Does Facebook need a chief privacy officer with the authority to take action on behalf of users?

 

QUESTION 2: Who owns user data on Facebook, the company or the users? If it’s the latter, why shouldn’t Facebook allow people to opt out of being targeted by ads?

 

CONTEXT: Facebook collects data on its own (your likes, which ads you click on, etc.); keeps data you share yourself (photos, videos, messages); and correlates data from outside sources to data on its platform (email lists from marketers, and until recently, information from credit agencies).

 

Who owns what is a difficult question to answer, and Facebook clearly hasn’t been good at explaining it. While you can download everything the company knows about you, it doesn’t really allow you to take “your” data to a rival.

Sandberg told Today’s Savannah Guthrie that given Facebook’s ad-driven business model, you can’t currently avoid data mining of your public profile information. (You can opt not to see the resulting targeted ads , though.) Allowing that, Sandberg said, would effectively require Facebook to turn into a “paid product” that charges users.

POSSIBLE FOLLOW-UP: Don’t other businesses allow some users to opt out of ads? Why can’t Facebook charge users who want ad-free experiences the way Hulu and YouTube do?

QUESTION 3: Facebook has made connecting with others and sharing information dead simple. Why haven’t you put similar effort into making your privacy controls equally easy to use?

 

CONTEXT: Facebook has updated its privacy settings seven times in the last decade, each time aimed at making them simpler to use.

 

The latest update was on March 28. On April 4, the company announced new technical changes designed to close loopholes that allowed third parties overbroad access to user data.

 

Facebook makes many pieces of information your profile public by default; to lock them down, you have to change those settings yourself.

 

POSSIBLE FOLLOW-UP: Does this legacy suggest the government needs to step in with clear and universal privacy rules?

 

QUESTION 4: Did Facebook threaten legal action against the Guardian newspaper in the U.K. regarding its reporting on the Cambridge Analytica scandal?

 

CONTEXT: John Mulholland, editor of the Guardian US, tweeted in March that Facebook had threatened to sue to stop publication of its story that broke the Cambridge Analytica scandal in mid-March. Neither the Guardian nor Facebook have commented further.

 

POSSIBLE FOLLOW-UP: Do you still stand behind Facebook’s actions here?

QUESTION 5: Have you spoken with critics, including some former Facebook investors and colleagues, who argue that the company’s service has become an addictive and corrosive force in society?

 

CONTEXT: Sean Parker, Facebook’s first president, said Facebook specializes in “exploiting” human psychology and may be harming our children’s brains. An early investor in Facebook, Roger McNamee compared Facebook to an addictive substance such as nicotine and alcohol.

 

Brian Acton, a co-founder of WhatsApp (acquired by Facebook in 2014), recently recommended that people should delete their Facebook accounts . Chamath Palihapitiya, an early vice president at Facebook, said Facebook’s tools are “ripping apart the social fabric.”

 

POSSIBLE FOLLOW-UP:  If not, why not?

 

Scientists Harvest First Vegetables in Antarctic Greenhouse

Scientists in Antarctica have harvested their first crop of vegetables grown without earth, daylight or pesticides as part of a project designed to help astronauts cultivate fresh food on other planets.

Researchers at Germany’s Neumayer Station III say they’ve picked 3.6 kilograms (8 pounds) of salad greens, 18 cucumbers and 70 radishes grown inside a high-tech greenhouse as temperatures outside dropped below -20 degrees Celsius (-4 Fahrenheit).

The German Aerospace Center DLR, which coordinates the project, said Thursday that by May scientists hope to harvest 4-5 kilograms of fruit and vegetables a week.

While NASA has successfully grown greens on the International Space Station, DLR’s Daniel Schubert says the Antarctic project aims to produce a wider range of vegetables that might one day be grown on Mars or the Moon.