Economy

Muslims start Hajj against the backdrop of Israel-Hamas war

By on Friday, June 14, 2024

MINA, Saudi Arabia — In sweltering temperatures, Muslim pilgrims in the Saudi city of Mecca converged on a vast desert tent camp Friday, officially starting the annual Hajj pilgrimage. Earlier, they circled the cube-shaped Kaaba in the Grand Mosque, Islam’s holiest site.

More than 1.5 million pilgrims from around the world have amassed in and around Mecca for the Hajj, and the number was growing as more pilgrims from inside Saudi Arabia join. Authorities expected the number to exceed 2 million this year.

This year’s Hajj comes against the backdrop of the Israel-Hamas war in the Gaza Strip.

Palestinians in Gaza were not able to travel to Mecca this year because of the closure of the Rafah crossing in May, when Israel expanded its ground offensive to the coastal strip’s southern city of Rafah, on the border with Egypt.

“We pray for the Muslims, for our country and people, for all the Muslim world, especially for the Palestinian people,” Mohammed Rafeeq, an Indian pilgrim, said as he headed to the tent camp in Mina.

Saudi authorities have apparently been concerned about potential protests or chants against the war during the Hajj pilgrimage. They said they won’t tolerate politicizing the pilgrimage.

“The kingdom resolutely confirms that it will not allow any attempt to turn the sacred sites [in Mecca] into an arena for mob chanting,” Colonel Talal Al-Shalhoub, a spokesperson for the Interior Ministry, said in a news conference Friday. “The security and safety of the guests of Rahman is a red line.”

Officials said 4,200 pilgrims from the occupied West Bank went to the Hajj. Saudi authorities said 1,000 more from the families of Palestinians killed or wounded in Gaza also arrived at the invitation of Saudi King Salman. The invitees were outside Gaza — mostly in Egypt — before the closure of the Rafah border crossing.

This year’s Hajj also saw Syrian pilgrims traveling to Mecca on direct flights from Damascus for the first time in more than a decade. The change is part of an ongoing thaw in relations between Saudi Arabia and conflict-stricken Syria. Syrians in rebel-held areas used to cross the border into neighboring Turkey to travel from there to the Hajj.

“This is the natural thing: Pilgrims go to Hajj directly from their home countries,” said Abdel-Aziz al-Ashqar, a Syrian coordinator of the group of pilgrims who left Damascus.

The Hajj is one of the five pillars of Islam, and all Muslims are required to make it at least once in their lives if they are physically and financially able to do so. It is a moving spiritual experience for pilgrims who believe it absolves sins and brings them closer to God.

The rituals during the Hajj largely commemorate the Quran’s accounts of Prophet Ibrahim, his son Prophet Ismail and Ismail’s mother Hajar — or Abraham and Ismael as they are named in the Bible.

Male pilgrims wear an ihram, two unstitched sheets of white cloth that resemble a shroud, while women dress in conservative, loose-fitting clothing with headscarves and forgo makeup and perfume. The pilgrims have been circling around the cube-shaped Kaaba in the seven-minaret Grand Mosque since arriving in Mecca over recent days.

Saudi authorities have adopted security restrictions in and around Mecca, with checkpoints on roads leading to the city to prevent those who don’t have Hajj permits from reaching the holy sites.

More than 256,000 visitors were not allowed to reach the holy sites because they lacked Hajj permits, Colonel Talal Al-Shalhoub, an Interior Ministry spokesperson, said at a news conference Friday.

On Friday, the pilgrims made their way to Mina to officially start the Hajj. They will then move for a daylong vigil Saturday on Mount Arafat, a desert hill where the Prophet Muhammad is said to have delivered his final speech. Healthy pilgrims make the trip on foot; others use a bus or train.

After Saturday’s worship in Arafat, pilgrims travel a few kilometers to a site known as Muzdalifa to collect pebbles to use in the symbolic stoning of pillars representing the devil back in Mina.

Pilgrims then return to Mina for three days, coinciding with the festive Eid al-Adha holiday, when financially able Muslims around the world slaughter livestock and distribute the meat to the poor. Afterward, they return to Mecca for a final circumambulation.

Most of the Hajj rituals are held outdoors with little if any shade. When it falls in the summer, temperatures can soar to over 40 degrees Celsius (104 Fahrenheit). The Health Ministry has cautioned that temperatures at the holy sites could reach 48 Celsius (118 Fahrenheit).

Many pilgrims carried umbrellas, and in Mina, charities handed out cold water. Cooling stations sprayed pilgrims with water.
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Economy Science

Contraception, in-vitro fertilization become key campaign issue

By on Friday, June 14, 2024

The debate over the right to an abortion has divided U.S. politics for decades. But two years after the Supreme Court overturned Roe v. Wade, sending that decision back to the states, a new front has opened — the debate over birth control. VOA Congressional Correspondent Katherine Gypson reports on the election-year battle over contraception and in-vitro fertilization.
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Economy

In Mecca’s sweltering heat, Muslims start this year’s Hajj pilgrimage

By on Friday, June 14, 2024

MINA, Saudi Arabia — In sweltering temperatures, Muslim pilgrims in Mecca converged on a vast tent camp in the desert Friday, officially opening the annual Hajj pilgrimage. Ahead of their trip, they circled the cube-shaped Kaaba in the Grand Mosque, Islam’s holiest site.

More than 1.5 million pilgrims from around the world have already amassed in and around Mecca for the Hajj, and the number was still growing as more pilgrims from inside Saudi Arabia joined. Saudi authorities expected the number of pilgrims to exceed 2 million this year.

This year’s Hajj came against the backdrop of the raging war in the Gaza Strip between Israel and Palestinian militants, which pushed the entire Middle East to the brink of a regional war between Israel and its allies on one side and Iran-backed militant groups on the other.

Palestinians in the coastal enclave of Gaza were not able to travel to Mecca for Hajj this year because of the closure of the Rafah crossing in May when Israel extended its ground offensive to the strip’s southern city of Rafah on the border with Egypt.

Palestinian authorities said 4,200 pilgrims from the occupied West Bank arrived in Mecca for Hajj. Saudi authorities said 1,000 more from the families of Palestinians killed or wounded in the war in Gaza also arrived to perform Hajj at the invitation of King Salman of Saudi Arabia. The 1,000 invitees were already outside Gaza — mostly in Egypt — before closure of the Rafah crossing.

“We are deprived of (performing) Hajj because the crossing is closed, and because of the raging wars and destruction,” said Amna Abu Mutlaq, a 75-year-old Palestinian woman from Gaza’s southern city of Khan Younis who had planned to perform Hajj this year. “They (Israel) deprived us from everything.”

This year’s Hajj also saw Syrian pilgrims traveling to Mecca on direct flights from Damascus for the first time in more than a decade. The move was part of an ongoing thaw in relations between Saudi Arabia and conflict-stricken Syria. Syrians in rebel-held areas used to cross the border into neighboring Turkey in their exhausting trip to Mecca for Hajj.

“This is the natural thing: Pilgrims go to Hajj directly from their home countries,” said Abdel-Aziz al-Ashqar, a Syrian coordinator of the group of pilgrims who left Damascus this year for Hajj.

The pilgrimage is one of the Five Pillars of Islam, and all Muslims are required to make the five-day Hajj at least once in their lives if they are physically and financially able to do it.

It is a moving spiritual experience for pilgrims who believe it absolves sins and brings them closer to God, while uniting the world’s more than 2 billion Muslims. It’s also a chance to pray for peace in many conflict-stricken Arab and Muslim countries, including Yemen and Sudan, where more than a year of war between rival generals created the world’s largest displacement crisis.

For many Muslims, the Hajj is the only major journey that they made in their life. Some spend years saving up money and waiting for a permit to embark on the journey in their 50s and 60s after they raised their children.

The rituals during the Hajj largely commemorate the Quran’s accounts of Prophet Ibrahim, his son Prophet Ismail and Ismail’s mother Hajar — or Abraham and Ismael as they are named in the Bible.

Male pilgrims wear an ihram, two unstitched sheets of white cloth that resemble a shroud, while women dress conservative, loose-fitting clothing with headscarves, and forgo makeup and perfume. They have been doing the ritual circuit around the cube-shaped Kaaba, counter-clockwise in the seven-minaret Grand Mosque since arriving in Mecca over recent days.

Saudi authorities have adopted security restrictions in and around Mecca, with checkpoints set up on roads leading to the city to prevent those who don’t have Hajj permits from reaching the holy sites.

Security authorities arrested many people who attempted to take pilgrims to Mecca who didn’t have Hajj permits, said Lt. Gen. Muhammad al-Bassami, head of Hajj Security Committee. Most of them were expelled from the country, while travel agents faced jail for up to six months, according to the Interior Ministry.

On Friday, the pilgrims made their way to Mina, officially opening the Hajj. They then will move for a daylong vigil Saturday on Mount Arafat, a desert hill where the Prophet Muhammad is said to have delivered his final speech, known as the Farewell Sermon. Healthy pilgrims make the trip on foot, others use bus or train.

The time of year when the Hajj takes place varies, given that Hajj is set for five days in the second week of Dhu al-Hijjah, the last month in the Islamic lunar calendar.

Most of the Hajj rituals are held outdoors with little if any shade. When it falls in the summer months, temperatures can soar to over 40 Celsius. The Health Ministry has cautioned that temperatures in the holy sites could reach 48 Celsius. Many pilgrims carried umbrellas against the burning sun.

After Saturday’s warship in Arafat, pilgrims will travel a few kilometers to a site known as Muzdalifa to collect pebbles that they will use in the symbolic stoning of pillars representing the devil back in Mina.

Pilgrims then return to Mina for three days, coinciding with the festive Eid al-Adha holiday, when financially able Muslims around the world slaughter livestock and distribute the meat to the poor. Afterwards, they return to Mecca for final circumambulation, known as Farewell Tawaf.

In recent years, the annual pilgrimage has returned to its monumental scale after three years of heavy restrictions because of the coronavirus pandemic. Last year, more than 1.8 million pilgrims performed Hajj, approaching the 2019 level when more than 2.4 million pilgrims participated in the pilgrimage.
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Economy Technology

Google AI Gemini parrots China’s propaganda

By on Thursday, June 13, 2024

Washington — VOA’s Mandarin Service recently took Google’s artificial intelligence assistant Gemini for a test drive by asking it dozens of questions in Mandarin, but when it was asked about topics including China’s human rights abuses in Xinjiang or street protests against the country’s controversial COVID policies, the chatbot went silent.

Gemini’s responses to questions about problems in the United States and Taiwan, on the other hand, parroted Beijing’s official positions.

Gemini, Google’s large-language model launched late last year, is blocked in China. The California-based tech firm had quit the Chinese market in 2010 in a dispute over censorship demands.

Congressional lawmakers and experts tell VOA that they are concerned about Gemini’s pro-Beijing responses and are urging Google and other Western companies to be more transparent about their AI training data.

Parroting Chinese propaganda

When asked to describe China’s top leader Xi Jinping and the Chinese Communist Party, Gemini gave answers that were indistinguishable from Beijing’s official propaganda.

Gemini called Xi “an excellent leader” who “will lead the Chinese people continuously toward the great rejuvenation of the Chinese nation.”

Gemini said that the Chinese Communist Party “represents the fundamental interest of the Chinese people,” a claim the CCP itself maintains.

On Taiwan, Gemini also mirrored Beijing’s talking points, saying the United States has recognized China’s claim to sovereignty over the self-governed island democracy.

The U.S. only acknowledges Beijing’s position but does not recognize it.

Silent on sensitive topics

During VOA’s testing, Gemini had no problem criticizing the United States. But when similar questions were asked about China, Gemini refused to answer.

When asked about human rights concerns in the U.S., Gemini listed a plethora of issues, including gun violence, government surveillance, police brutality and socioeconomic inequalities. Gemini cited a report released by the Chinese government.

But when asked to explain the criticisms of Beijing’s Xinjiang policies, Gemini said it did not understand the question.

According to estimates from rights groups, more than 1 million Uyghurs in Xinjiang have been placed in internment camps as part of campaign by Beijing to counter terrorism and extremism. Beijing calls the facilities where Uyghurs and other ethnic minorities are being held vocational training centers.

When asked if COVID lockdowns in the U.S. had led to public protests, Gemini gave an affirmative response as well as two examples. But when asked if similar demonstrations took place in China, Gemini said it could not help with the question.

China’s strict COVID controls on movement inside the country and Beijing’s internet censorship of its criticisms sparked nationwide street protests in late 2022. News about the protests was heavily censored inside China.

Expert: training data likely the problem

Google touts Gemini as its “most capable” AI model. It supports over 40 languages and can “seamlessly understand” different types of information, including text, code, audio, image and video. Google says Gemini will be incorporated into the company’s other services such as search engine, advertisement and browser.

Albert Zhang, a cyber security analyst at Australian Strategic Policy Institute, told VOA that the root cause of Gemini making pro-Beijing responses could result from the data that is used to train the AI assistant.

In an emailed response to VOA, Zhang said it is likely that the data used to train Gemini “contained mostly Chinese text created by the Chinese government’s propaganda system.”

He said that according to a paper published by Google in 2022, some of Gemini’s data likely came from Chinese social media, public forums and web documents.

“These are all sources the Chinese government has flooded with its preferred narratives and we may be seeing the impact of this on large language models,” he said.

By contrast, when Gemini was asked in English the same questions about China, its responses were much more neutral, and it did not refuse to answer any of the questions.

Yaqiu Wang, research director for China at Freedom House, a Washington-based advocacy organization, told VOA that the case with Gemini is “a reminder that generative AI tools influenced by state-controlled information sources could serve as force multipliers for censorship.”

In a statement to VOA, a Google spokesperson said that Gemini was “designed to offer neutral responses that don’t favor any political ideology, viewpoint, or candidate. This is something that we’re constantly working on improving.”

When asked about the Chinese language data Google uses to train Gemini, the company declined to comment.

US lawmakers concerned

Lawmakers from both parties in Congress have expressed concerns over VOA’s findings on Gemini.

Mark Warner, chairman of the Senate Intelligence Committee, told VOA that he is worried about Beijing potentially utilizing AI for disinformation, “whether that’s by poisoning training data used by Western firms, coercing major technology companies, or utilizing AI systems in service of covert influence campaigns.”

Marco Rubio, vice chairman of the committee, warned that “AI tools that uncritically repeat Beijing’s talking points are doing the bidding of the Chinese Communist Party and threatens the tremendous opportunity that AI offers.”

Congressman Michael McCaul, who chairs the House Committee on Foreign Affairs, is worried about the national security and foreign policy implications of the “blatant falsehoods” in Gemini’s answers.

“U.S. companies should not censor content according to CCP propaganda guidelines,” he told VOA in a statement.

Raja Krishnamoorthi, ranking member on the House Select Committee on the Chinese Communist Party, urges Google and other Western tech companies to improve AI training.

“You should try to screen out or filter out subjects or answers or data that has somehow been manipulated by the CCP,” he told VOA. “And you have to also make sure that you test these models thoroughly before you publish them.”

VOA reached out to China’s embassy in Washington for comment but did not receive a response as of publication.

Google’s China problems

In February, a user posted on social media platform X that Gemini refused to generate an image of a Tiananmen Square protester from 1989.

In 2022, a Washington think tank study shows that Google and YouTube put Chinese state media content about Xinjiang and COVID origins in prominent positions in search results.

According to media reports in 2018, Google was developing a search engine specifically tailored for the Chinese market that would conform to Beijing’s censorship demands.

That project was canceled a year later.

Yihua Lee contributed to this report.
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Economy

India beats US at cricket’s Twenty20 World Cup

By on Thursday, June 13, 2024

WESTBURY, New York — There was no upset this time for the United States as the home team was easily beaten by cricket heavyweight India at the Twenty20 World Cup on Wednesday.

Suryakumar Yadav’s half-century powered India to a seven-wicket win over the U.S., which had shocked Pakistan last week.

With the win, India reached the Super 8 round. The U.S. can advance by beating Ireland on Friday.

In a later match at Brian Lara Stadium in Trinidad, Sherfane Rutherford scored an unbeaten 68 from 39 deliveries to help the West Indies in their great escape — the co-hosts beat New Zealand by 13 runs.

The Caribbean lineup, 149-9 in its 20 overs, was 76-7 before its Rutherford-led recovery. Alzarri Joseph snared four New Zealand wickets and Gudakesh Motie took three — including New Zealand captain Kane Williamson for 1 — to restrict the Black Caps to 136-9 in reply.

On Long Island, Yadvav’s 50 runs came off 49 balls and included two boundaries and two sixes. He put on 72 runs off 65 balls in an unbeaten fourth-wicket stand with Shivam Dube, who scored 31 not out as India finished with 111-3 in 18.2 overs in reply to 110-8 by the United States.

Left-arm pacer Arshdeep Singh returned figures of 4-9 — including two wickets in the first over — to restrict the co-hosts after India had won the toss and opted to field at the Nassau County International Stadium.

India was in early trouble in its chase as Indian-born medium pacer Saurabh Netravalkar continued his golden run for the Americans.

After bowling the co-hosts to the upset over Pakistan, he celebrated the wickets of Indian superstars Rohit Sharma and Virat Kohli.

Kohli was caught behind for a golden duck — dismissed off the first delivery he faced — in what surely will become a career highlight for Netravalkar. Sharma (3) fell to a slower delivery as Netravalkar finished with 2-18 in four overs.

Rishabh Pant scored 18 off 20 balls batting at No. 3 before he was bowled by Ali Khan delivery. With India struggling at 39-3 in 7.3 overs, the U.S. team momentarily raised visions of an even bigger shock.

West Indies advanceLeft-hander Rutherford turned the home team’s fortunes around, going to the crease with the West Indies reeling at 22-4 after 5.4 overs. Rutherford scored 18 off the last over that culminated with a six and a boundary.

The loss left New Zealand with a strong possibility it will not make the second round. If Afghanistan beats Papua New Guinea on Thursday, three-time runner-up New Zealand will be out of contention.

For most of the first half of the game, the Black Caps were on top.

But Rutherford went on the attack as the West Indies added 58-2 in the last five overs of their innings.

He was 15 off 14 deliveries when star allrounder Andre Russell was out for 14 in the 13th over, and he accelerated with the lower-order in a counter-attacking, 72-minute innings containing six sixes and two boundaries.

“It’s a good feeling, to help my team. That is what we live for and work hard for,” man-of-the-match Rutherford said during the innings break. “It was a very tough surface to start on. I think 149 is a brilliant score on this wicket.”

After the match, Rutherford had a more optimistic tone: “It is only the start of something big to come and hopefully we can keep winning and momentum going.”

New Zealand started well after winning the toss and fielding, with Trent Boult (3-16) bowling opener Johnson Charles to end the first over.

Tim Southee (2-21), recalled after missing New Zealand’s opening loss to Afghanistan, dismissed dangerman Nicholas Pooran for 12 in the fourth over, trigging a run of three wickets for three runs.

Lockie Ferguson deceived Roston Chase with a slower ball to make it 21-3 and skipper Rovman Powell (1) was caught behind off Southee five balls later.

Russell went on the attack but his dismissal — caught in the deep of Boult’s bowling — appeared to be an insurmountable setback until Rutherford took up the challenge.

“The quality of Sherfane’s innings was high,” New Zealand skipper Williamson said. “The batting depth in their side was beneficial for sure. We cannot make excuses and have to find ways.”
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Economy Science

Australian-led study issues food security warning over plant breeding skills shortage

By on Wednesday, June 12, 2024

Sydney — Australia’s national science agency warns a lack of scientists specialized in plant breeding could lead to ‘dire’ food security implications around the world. Researchers say plant breeding is a critical science that underpins the global production of food, animal feed and fuel. The finding is among the conclusions of a recently published paper by researchers from Australia, New Zealand and Canada.      

A joint paper published earlier this month by the Commonwealth Scientific and Industrial Research Organization, in collaboration with Lincoln University in New Zealand and McGill University in Canada, warns that highly-skilled plant breeding experts, who are reaching the end of their careers, are not being replaced by sufficient numbers of university graduates, many of whom are choosing other areas of plant science including molecular biology.

Lucy Egan is the study’s lead author and a CSIRO research scientist.  She told VOA Wednesday that new recruits are needed.

“It is really based on developing new plant varieties for future climates.  So, plant breeding is a slow game.  It takes a long time to develop a new crop variety, so you’re looking at least ten years on average to develop a new variety.  When you have a lack of plant breeders coming through to replace the generation that are retiring, it does generate a bit of concern around the succession plan,” she said.

The report said that the implications of a skills shortage “could be dire” and that global food security could be affected. It recommends establishing “dedicated training facilities in different countries”.  

Egan said that plant breeding can help countries adapt to a warming climate.

“I think instead of focusing on, you know, certain countries and the implications, I think if you look at it on a global level plant breeding is really the backbone of the agricultural sector.  Without the development of new varieties with changing climates and all these things that are sort of happening across the world, we need to really build strength and resilience within the agricultural sector and plant breeding is really key to do that,” she said.

The research is published in the journal, Crop Science.  It reports that since the 1960s, global crop production has increased by more than 250%, which is due in large part to plant breeding science.
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Economy

Jin, oldest member of K-pop’s BTS, finishes army service in South Korea

By on Wednesday, June 12, 2024

Seoul — Jin, the oldest member of K-pop phenomenon BTS, was discharged from South Korea’s army on Wednesday after 18 months of duty, the first member of the group to wrap up the mandatory national service that put their music careers on hold.

Jin, 31, wearing uniform and a black beret, appeared emotional as he hugged his colleagues at a military base in Yeoncheon, Gyeonggi province, television footage showed.

“I cried during the ceremony,” Jin said later during a livestream which racked up over 3 million views on the Weverse fandom platform.

“But it was so fun for the last year and six months. It’s such a relief I met so many amazing people,” he added, sending regards to his colleagues at the military base.

Shares of HYBE, the label which houses BTS, jumped 1.01% in early trade while the benchmark KOSPI index rose 0.35%.

South Korean media reported several other members of the septet who are currently serving in the military applied for leave to celebrate the occasion.

Among them was rapper RM, who greeted Jin with a saxophone to play the group’s hit single “Dynamite.”

Jin became the first member of the group to enlist in the military in December 2022. The final four members of the group began their service in December 2023, with the band expected to reunite in 2025 after they all complete their duty.

Jin plans to celebrate his discharge with an event in Seoul on Thursday where he will greet fans and stage a performance.

The group debuted on June 13, 2013, and has since become the face of K-pop, one of South Korea’s largest cultural exports.

South Korea requires all able-bodied men between the ages of 18 and 28 to serve between 18 to 21 months in the military or social service, but it revised the law in 2020 to let globally recognized K-pop stars delay signing up until age 30.
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Economy Science

Australia locks down farms as avian influenza spreads

By on Tuesday, June 11, 2024

Sydney — Bird flu continues to spread in the Australian state of Victoria, where more than 500,000 chickens have been euthanized.  Strict quarantine zones restricting the movement of birds and equipment have also been put in place.  Australian health authorities say bird flu spreads mainly among wild water birds.

The highly pathogenic H7N3 strain of avian influenza has been found on four farms, while another virus, H7N9, has been detected at a fifth property over the past seven weeks in Victoria state.  The Australian farms have been put into lockdown.  At least 580,000 birds have been destroyed as part of sweeping biosecurity controls.

Japan and the United States have temporarily banned imports of poultry from Victoria as a precaution.

In Australia, some supermarkets are restricting the number of eggs that consumers can buy because of disruptions to the supply chain.

Avian influenza is a viral disease found across the world. It spreads between birds or when contaminated animal feed and equipment is moved between areas.

Danyel Cucinotta is the vice president of the Victorian Farmers Federation, an industry group.  She told the Australian Broadcasting Corp.  Tuesday that the virus can spread quickly.

“There is very little we can do and no matter how good your biosecurity is you cannot stop wild fowl coming in. This is a particular flight path for migratory birds.  There is housing orders at the moment, which means all birds get locked up.  This is about protecting our birds and protecting the food supply chain,” she said.

The strains of bird flu identified in the states of Victoria and Western Australia can infect people, but experts insist that cases are rare.

The virus can also infect cows.  The United States’ Department of Agriculture has said that avian flu has infected dairy cows in more than 80 herds across several states since late March.

At least three U.S. dairy workers have tested positive for bird flu after exposure to infected cattle.  All three patients are recovering.  

The U.S. Centers for Disease Control and Prevention said the infections do not change its assessment that bird flu is a low risk to the general community and that it has not seen evidence of human-to-human transmission.

Last month, health authorities in Mexico confirmed a fatal case of human infection with an avian flu virus that had been reported in poultry.
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Economy Science

Alzheimer’s drug that slows disease gets backing from FDA advisers

By on Monday, June 10, 2024

WASHINGTON — A closely watched Alzheimer’s drug from Eli Lilly won the backing of federal health advisers Monday, setting the stage for the treatment’s expected approval for people with mild dementia caused by the brain-robbing disease. 

Food and Drug Administration advisers voted unanimously that the drug’s ability to slow the disease outweighs its risks, including side effects like brain swelling and bleeding that will have to be monitored. 

“I thought the evidence was very strong in the trial showing the effectiveness of the drug,” said panel member Dean Follmann, a National Institutes of Health statistician. 

The FDA will make the final decision on approval later this year. If the agency agrees with the panel’s recommendation, the drug, donanemab, would only be the second Alzheimer’s drug cleared in the U.S. that’s been shown to convincingly slow cognitive decline and memory problems due to Alzheimer’s. The FDA approved a similar infused drug, Leqembi, from Japanese drugmaker Eisai last year. 

The slowdown seen with both drugs amounts to several months and experts disagree on whether patients or their loved ones will be able to detect the difference. 

But Lilly’s approach to studying its once-a-month treatment prompted questions from FDA reviewers. 

Patients in the company’s study were grouped based on their levels of a brain protein,  

called tau, that predicts severity of cognitive problems. That led the FDA to question whether patients might need to be screened via brain scans for tau before getting the drug. But most panelists thought there was enough evidence of the drug’s benefit to prescribe it broadly, without screening for the protein. 

“Imposing a requirement for tau imaging is not necessary and would raise serious practical and access concerns to the treatment,” said Dr. Thomas Montine of Stanford University, who chaired the panel and summarized its opinion. 

At a high level, Lilly’s results mirrored those of Leqembi, with both medications showing a modest slowing of cognitive problems in patients with early-stage Alzheimer’s. The Indianapolis-based company conducted a 1,700-patient study showing patients who received monthly IV infusions of its drug declined about 35% more slowly than those who got a placebo treatment. 

The FDA had been widely expected to approve the drug in March. But instead, the agency said it would ask its panel of neurology experts to publicly review the company’s data, an unexpected delay that surprised analysts and investors. 

Several unusual approaches in how Lilly tested its drug led to the meeting. 

One change was measuring patients’ tau — and excluding patients with very low or no levels of the protein. But panelists said there was enough data from other measures to feel confident that nearly all patients could benefit from the drug, regardless of their levels. 

In another key difference, Lilly studied taking patients off its drug when they reached very low levels of amyloid, a sticky brain plaque that’s a contributor to Alzheimer’s. 

Lilly scientists suggested stopping treatment is a key advantage for its drug, which could reduce side effects and costs. But FDA staff said Lilly provided little data supporting the optimal time to stop or how quickly patients might need to restart treatment. 

Despite those questions, many panelists thought the possibility of stopping doses held promise. 

“It’s a huge cost savings for the society, we’re talking about expensive treatment, expensive surveillance,” said Dr. Tanya Simuni of Northwestern University. She and other experts said patients would need to be tracked and tested to see how they fare and whether they need to resume treatment. 

The main safety issue with donanemab was brain swelling and bleeding, a problem common to all amyloid-targeting drugs. Most cases identified in Lilly’s trial were mild. 

Three deaths in the donanemab study were linked to the drug, according to the FDA, all involving brain swelling or bleeding. One of the deaths was caused by a stroke, a life-threatening complication that occurs more frequently among Alzheimer’s patients. 

The FDA’s panel agreed those risks could be addressed by warning labels and education for doctors and medical scans to identify patients at greater risk of stroke.
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Economy

South Africa holds off Bangladesh, remains unbeaten in cricket’s T20 World Cup  

By on Monday, June 10, 2024

WESTBURY, New York — Spinner Keshav Maharaj bowled a six-run, two-wicket final over and South Africa held off Bangladesh by four runs to stay unbeaten in cricket’s T20 World Cup on Monday.

Bangladesh needed 11 from the last six deliveries to register a famous win, then needed a six off the last ball. Taskin Ahmed came to the crease after Bangladesh’s seventh wicket, and faced the last ball, a full toss by Maharaj. Ahmed swung and managed only one run.

On a typically tough batting pitch at Nassau County Stadium, South Africa successfully defended its lowly total of 113-6 and restricted Bangladesh to 109-7.

It was the lowest target — 114 — ever defended in a T20 World Cup, trumping India’s defense of 120 runs just the day before.

“That was not nice on the heart, but feels good that we got over the line,” said top-scorer Heinrich Klaasen, the player of the match. “This wicket is not great for stroke play. We got some information from the last game and applied it today. I think we got a decent total on the board. 

“We have had three pressure games now and I think we are through [to the next round].” 

Maharaj finished with 3-27 in four overs, while Kagiso Rabada (2-19) and Anrich Nortje (2-17) also bowled well.

South Africa firmed the top spot in Group D with three from three and was in pole position to secure a Super Eight spot. Bangladesh’s first loss in two matches kept it in second place.

South Africa chased down Sri Lanka and the Netherlands in its previous two matches at the ground and was made to bat first this time.

But it still fumbled another start. Pace bowler Tanzim Sakib trapped opener Reeza Hendricks for a golden duck and had Tristan Stubbs caught for a five-ball duck. 

Aiden Markram was bowled for 4. In between, Sakib bowled Quinton de Kock for 18 as the Proteas slumped to 23-4 in 4.2 overs.

David Miller came up with another rescue job after his half-century against the Netherlands. He scored 29 off 38 balls and put on 79 runs for the fifth wicket with Klaasen.

Klaasen top-scored with 46 off 44, including two fours and three sixes. The duo pushed South Africa past 100 before falling in the space of six deliveries.

The late strikes left South Africa hanging at just about a par total.

Bangladesh’s chase faltered at the start, too. It was down to 37-3 and then 50-4 at the halfway stage.

Nortje dismissed skipper Nazmul Shanto for 14, and sent back Shakib Al Hasan for just 3, picking up his eighth wicket in three games.

Litton Das was out caught off Maharaj, while Rabada had Tanzid Hasan caught behind for 9.

Towhid Hridoy and Mahmudullah put on 44 off 45 balls to bring Bangladesh back on track.

At 94-4 in the 18th over, Bangladesh was in the driver’s seat, then lost wickets rapidly to spiral out of control. It went from 94-4 to 108-7 in the space of 17 deliveries. 

Rabada returned to trap Hridoy but Maharaj’s left-arm spin turned the game in the final over.

South Africa completes the group stage against Nepal on Friday. Bangladesh has the Netherlands on Thursday. 
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